Safety and Immunogenicity of a Nipah Virus Vaccine

Condition:   Nipah Virus Infection Interventions:   Biological: HeV-sG-V;   Biological: Normal Saline Placebo Sponsors:   Profectus BioSciences, Inc.;   PATH;   Coalition for Epidemic Preparedness Initiative (CEPI);   Cincinnati Children's Hospital Medical Center (CCHMC) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Licensed vaccines or therapeutics are rarely available for pathogens with epidemic or pandemic potential. Developing interventions for specific pathogens and defining generalizable approaches for related pathogens is a global priority and inherent to the UN Sustainable Development Goals. Nipah virus (NiV) poses a significant epidemic threat, and zoonotic transmission from bats-to-humans with high fatality rates occurs almost annually. Human-to-human transmission of NiV has been documented in recent outbreaks leading public health officials and government agencies to declare an urgent need for effective vaccines and therape...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
By Anis Chowdhury and Jomo Kwame SundaramSYDNEY and KUALA LUMPUR, Apr 9 2020 (IPS) Within weeks, the Covid-19 epidemic was classified by the World Health Organization (WHO) as an epidemic of international significance, triggering a pre-agreed WHO response. By the end of the first week of April, more than 1.3 million people had been confirmed as infected, with over 65,000 deaths across the world. Anis Chowdhury Many governments of developing, especially poor countries are unsure what to do, fearing the likely economic consequences of the ‘lockdowns’ increasingly adopted by Western economies. Indeed, lockdowns m...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Civil Society Development & Aid Economy & Trade Featured Global Headlines Health Humanitarian Emergencies TerraViva United Nations Jomo Kwame Sundaram & Anis Chowdhury Source Type: news
Research in the last decade has uncovered many new paramyxoviruses, airborne agents that cause epidemic diseases in animals including humans. Most paramyxoviruses enter epithelial cells of the airway using sialic acid as a receptor and cause only mild disease. However, others cross the epithelial barrier and cause more severe disease. For some of these viruses, the host receptors have been identified, and the mechanisms of cell entry have been elucidated. The tetrameric attachment proteins of paramyxoviruses have vastly different binding affinities for their cognate receptors, which they contact through different binding s...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: JBC Reviews Source Type: research
Conclusion: The rapid spread of infection uncovered the miserable state of health care system in implementing infection control measures. The case fatality and the socio-economic burden warrant developing appropriate treatments, vaccines and diagnostics.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Abstract Launched at Davos in January 2017 with funding from sovereign investors and philanthropic institutions, the Coalition for Epidemic Preparedness Innovations (CEPI) is an innovative partnership between public, private, philanthropic, and civil organisations whose mission is to stimulate, finance and co-ordinate vaccine development against diseases with epidemic potential in cases where market incentives fail. As of December 2019, CEPI has committed to investing up to $706 million in vaccine development. This includes 19 vaccine candidates against its priority pathogens (Lassa fever virus, Middle East respir...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Condition:   Nipah Virus Infection Interventions:   Biological: HeV-sG-V;   Biological: Normal Saline Placebo Sponsors:   Profectus BioSciences, Inc.;   PATH;   Coalition for Epidemic Preparedness Initiative (CEPI);   Cincinnati Children's Hospital Medical Center (CCHMC) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
, Norheim G Abstract Today's world is characterized by increasing population density, human mobility, urbanization, and climate and ecological change. This global dynamic has various effects, including the increased appearance of emerging infectious diseases (EIDs), which pose a growing threat to global health security.Outbreaks of EIDs, like the 2013-2016 Ebola outbreak in West Africa or the current Ebola outbreak in Democratic Republic of the Congo (DRC), have not only put populations in low- and middle-income countries (LMIC) at risk in terms of morbidity and mortality, but they also have had a significant impa...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
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