Amylin and leptin interaction: role during pregnancy, lactation and neonatal development

Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Christina N. Boyle, Christelle Le FollAbstractAmylin is co-secreted with insulin by pancreatic β-cells in response to a meal and neurons in discrete hypothalamic brain areas have been shown to produce amylin. Leptin is proportionally secreted by the adipose tissue. Both hormones control food intake and energy homeostasis post-weaning in rodents. While amylin’s main site of action is located in the area postrema and leptin’s is located in the mediobasal hypothalamus, both hormones can also influence the other’s signaling pathway; amylin has been shown enhance hypothalamic leptin signaling and amylin signaling in the AP may rely on functional leptin receptors to modulate its effect. These two hormones also play major roles during other life periods. During pregnancy, leptin levels rise as a result of an increase in fat depot resulting in gestational leptin-resistance to prepare the body for the metabolic needs during the fetal development. Leptin levels decrease rapidly during the post-partum period and remaining elevated levels could predispose to post-partum depression. The role of amylin is far less studied during pregnancy and lactation, and amylin levels seem to be elevated during pregnancy relative to insulin. Whether amylin and leptin interact during pregnancy and lactation remains to be assessed. Last, during brain development, amylin and leptin are major regulators of cell birth du...
Source: Neuroscience - Category: Neuroscience Source Type: research