Psychogenic nonepileptic seizures that remit when the diagnosis is given: Just good luck?

Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Roderick Duncan, John Horwood, Saif Razvi, Sharon MulhernAbstractObjectiveSome patients with psychogenic nonepileptic seizures (PNES) remit when given the diagnosis. It is not realistically possible to test this potential therapeutic effect in an Randomized Controlled Trial (RCT) so we aim to statistically demonstrate it using the temporal relationship between the communication of the diagnosis and the timing of remission.MethodRe-analysis of data from a study of PNES, where diagnosis was communicated, and outcomes recorded in 54 patients. Making conservative assumptions and using the binomial distribution, the Poisson distribution and the chi-squared test distribution, we calculated likelihoods of the null hypothesis: that communication of the diagnosis and remission of seizures had occurred in random temporal relationship.ResultsRemission occurred in the week following communication of the diagnosis in 15 out of 54 patients. The χ2 test assigned this result a p value of
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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ConclusionTo the best of our knowledge, this is the first review dedicated to the characteristics of paediatric patients with PRS and epilepsy. Seizures are usually focal, became refractory in 40%, and have a significant impact on the quality of life and neurodevelopment of patients.
Source: Seizure - Category: Neurology Source Type: research
The objective of this study was to assess factors associated with research participation among epilepsy clinic patients who screened positive for anxiety or depression. This was accomplished by characterizing clinical and psychiatric factors among patients seen in an epilepsy clinic and evaluating which factors were associated with consent for potential research participation, via a combined clinical and research screening model.MethodsIn a pragmatic trial of anxiety and depression treatment in epilepsy, individuals with a positive screen for anxiety and/or depression at a routine epilepsy clinic visit were invited to opt-...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
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Source: CNS Drugs - Category: Neurology Source Type: research
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Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Clinical letter Source Type: research
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Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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