Rapamycin on the treatment of mucoepidermoid carcinomas and squamous cell carcinomas

Mucoepidermoid carcinomas (MEC) are the most common malignancy of the salivary glands. Dysfunctional clock signaling is observed in a variety of pathologic conditions. Members of the clock gene family are upregulated in tumor cells. We explored the role of the mTOR signaling pathway, commonly found upregulated in tumors including in MEC, oral squamous cell carcinomas (OSCC), and its population of cancer stem cells (CSC). We also explored the potential implication on the disruption of the mTOR signaling on the expression the clock gene family member BMAL1 in tumor behavior using the specific mTOR inhibitor rapamycin.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: LEONARDO AMARAL DOS REIS, RENATA LUCENA MARKMAN, LIANA PRETTO WEBBER, PABLO AGUSTIN VARGAS, JACKS JORGE, CRISTIANE HELENA SQUARIZE, ROGERIO CASTILHO Source Type: research