H3K27me3 loss plays a vital role in CEMIP mediated carcinogenesis and progression of breast cancer with poor prognosis

ConclusionsOur data suggest H3K27me3 loss as an important event in CEMIP mediated breast cancer carcinogenesis and progression. Loss of H3K27me3 is specific for aggressive subtypes of breast cancer and may be a useful diagnostic marker.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Authors: Sher AF, Golshani GM, Wu S Abstract Background: Pembrolizumab as an immune checkpoint inhibitor (ICI) has emerged as an effective treatment for many cancers. It has unique immune related adverse events and little is known about its risk of fatal adverse events (FAE). We conducted a meta-analysis of clinical trials to determine the incidence and risk of fatal adverse events with pembrolizumab.Methods: A systematic search for phase I-III clinical trials of pembrolizumab was conducted using databases including PUBMED, and abstracts presented at the American Society of Clinical Oncology (ASCO) conferences unti...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Source: Vascular Health and Risk Management - Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): V. Porchezhiyan, D. Kalaivani, J. Shobana, S.E. NoorjahanAbstractUnsymmetrical 1,3-diketones with potential anti-cancer as well as anti-inflammatory activities were synthesized via direct coupling reaction between ketones and N-acyl benzotriazoles, based on soft enolisation under mild conditions and characterized by 1H,13C NMR, IR and HRMS. Molecular docking of the synthesized compounds (5a-5j) with the enzymes PTK6 (breast cancer cell), COX-1 and COX-2 (inflammation and pain) revealed 5j to be the potent compound. It was found to ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
We report the isolation, characterization of bioactive small molecule ([crocetin (β-D-glucosyl) ester] from the leaf biowastes saffron plant of Kashmir, India. MTTC assay and Bio-autography aided approach were used to assess anticancer activity and anti-cancer properties of crocin (s) against DPPH free radical and breast cancer cell line respectively. Crocetin beta-D-glucosyl ester restrained proliferation of human breast adeno-carcinoma cell model (MCF-7) without significantly affecting normal cell line (L-6). This is further explained using molecular docking based predicted binding affinity of crocetin beta-D-g...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 28 January 2020Source: Chemico-Biological InteractionsAuthor(s): Qianqian Wang, Jianwei Zheng, June X. Zou, Jianzhen Xu, Fanghai Han, Songtao Xiang, Peiqing Liu, Hong-Wu Chen, Junjian WangAbstractEndocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxifen resistance in breast cancer cells and that NSD2 is a potential biomarker of t...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
ConclusionThe study indicates that IL-17 is overexpressed in intratumoral stromal cells of TNBC-NST. The overexpression of IL-17 might engage in active tumor microangiogenesis through its signal transduction pathways resulting in increased tumor secretion of VEGFA, and then promote tumor progression. IL-17 might serve as a potential new target for individualized therapy to TNBC-NST patients by development of specific antibodies. Additional study is deemed to further explore the role of IL-17+ stromal cells in breast cancer.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
PMID: 31985642 [PubMed - in process]
Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
CONCLUSIONS: Based on the available evidence, there is no increased risk of complications for elective hand surgery in patients with prior breast cancer treatment. Breast cancer patients with preexisting ipsilateral lymphedema carry slightly increased risk of postoperative infection and worsening lymphedema. It is the authors' opinion and recommendation that elective hand surgery with a tourniquet is not a contradiction in patients who have received previous breast cancer treatments. PMID: 31985641 [PubMed - in process]
Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
Publication date: 2020Source: European Journal of Radiology Open, Volume 7Author(s): Ryusuke Murakami, Nachiko Uchiyama, Hitomi Tani, Tamiko Yoshida, Shinichiro KumitaAbstractPurposeTo compare observer performance between synthetic mammography (2DSM) and full-field digital mammography (FFDM) for breast cancer detection and visibility.MethodA retrospective analysis was conducted on 136 histopathologically proven cases of breast cancer in patients who underwent FFDM and digital breast tomosynthesis (DBT). 2DSM images were reconstructed from DBT data, and 2DSM and FFDM images were reviewed and evaluated for mammographic featu...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
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