FEV1 recovery following methacholine challenge in asthma: Variability and comparison of methods

ConclusionMaximum reduction in FEV1 had the lowest variability. There was little difference between repetitions of the same methodology, as indicated by overlapping confidence intervals. There was a trend towards faster recovery following bolus challenge than with the incremental challenge. The results of this trial could be of value when designing future clinical trials using the methacholine challenge methodology.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research