Template Creation for High-Resolution Computed Tomography Scans of the Lung in R Software
Publication date: Available online 13 December 2019Source: Academic RadiologyAuthor(s): Sarah M. Ryan, Brian Vestal, Lisa A. Maier, Nichole E. Carlson, John MuschelliRationale and ObjectivesA standard lung template could improve population-level analyses for computed tomography (CT) scans of the lung. We develop a fully automated preprocessing pipeline for image analysis of the lungs using updated methodologies and R software that results in the creation of a standard lung template. We apply this pipeline to CT scans from a sarcoidosis population, exploring the influence of registration on radiomic analyses.Materials and MethodsUsing 65 high-resolution CT scans from healthy adults, we create a standard lung template by segmenting the left and right lungs, nonlinearly registering lung masks to an initial template mask, and using an unbiased, iterative procedure to converge to a standard lung shape (Dice similarity coefficient ≥0.99). We compare three-dimensional radiomic features between control and sarcoidosis patients, before and after registration to a study-specific lung template.ResultsThe final lung template had a right lung volume of 2967 cm3 and left lung volume of 2623 cm3, with a median HU = −862. Registration significantly affected radiomic features, shifting the HU distribution to the left, decreasing variability, and increasing smoothness (p
CONCLUSIONS: Pulmonary LCDD is characterized by cysts and nodules. The disease is associated with MALT lymphoma, especially in the setting of Sjögren syndrome. PMID: 32217287 [PubMed - as supplied by publisher]
ConclusionBone sarcoidosis occurred in 14% of patients with sarcoidosis, affecting multiple bones and mostly the axial skeleton.18F-FDG PET/CT seems a sensitive tool for diagnosis and follow-up of bone sarcoidosis.Key Points• Bone sarcoidosis is not rare.• Bone sarcoidosis affects mainly the axial skeleton.•18F-FDG PET/CT is useful for diagnosis and follow-up of bone sarcoidosis.
Authors: Elwazir MY, Bois JP, Abouezzeddine OF, Chareonthaitawee P Abstract Infiltrative heart disease is an encompassing term referring to different pathological entities that involve infiltration of the myocardium by either abnormal substances or inflammatory cells. These infiltrates can impair cellular function, induce necrosis and fibrosis, or otherwise disrupt myocardial architecture resulting in a wide spectrum of structural and functional impairment. Depending on the specific disorder and stage of disease, patients may present with minimal cardiac abnormalities, or may have findings of advanced restrictive a...
CONCLUSION: This review would illustrate the usefulness and limits of 18-F-FDG-PET/CT in the assessment of pulmonary sarcoidosis. PMID: 31964323 [PubMed - in process]
CONCLUSION: In this review, we would summarize in brief the clinical indications of PDG-PET in sarcoidosis and report the imaging features of the main organs involved in this disease. PMID: 31964321 [PubMed - in process]
We present a case of a 73-year-old male who initially presented with night sweats, intermittent fever, worsening dry cough and shortness of breath. CT scans revealed atelectasis and calcified mediastinal lymphadenopathy, raising a suspicion for sarcoidosis. Multiple lung biopsies were performed. Microscopically, atypical lymphocytes were identified within capillaries, small arteries and veins. These lymphocytes were large with prominent nucleoli. Immunohistochemical staining demonstrated tumor cells positive for CD20, CD79a, Pax-5, CD10 and Mum-1, while negative for CD3, cytokeratin, S100, and CD34. LDH serum level was inc...
ConclusionCommon variable immunodeficiency is a heterogeneous condition with a highly variable clinical phenotype and a strong association with autoimmune disorders. The presence of noncaseating granuloma and pulmonary lesions, along with extrapulmonary features required a step by step approach to differentiate between CVID and sarcoidosis. This enables early introduction of immunoglobulin replacement therapy and decreases the morbidity and mortality of CVID.
ConclusionsFMISO showed no physiological myocardial uptake and did not require special preparation. FMISO PET has the potential to detect hypoxic lesions in patients with sarcoidosis.
Conclusion: PET/CT added no significant additional benefit over Chest CT in patients with suspected OS or IOTB. PMID: 31743044 [PubMed - as supplied by publisher]
Conclusion: Awareness and identification of CVID associated respiratory abnormalities may guide therapy and improve prognosis.