Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos

Publication date: Available online 14 December 2019Source: Progress in NeurobiologyAuthor(s): Vijaykumar Yogesh Muley, Carlos Javier López-Victorio, Jorge Tonatiuh Ayala-Sumuano, Adriana González-Gallardo, Leopoldo González-Santos, Carlos Lozano-Flores, Gregory Wray, Maribel Hernández, Alfredo Varela-EchavarríaAbstractThe mammalian and the avian telencephalon are nearly indistinguishable at early embryonic vesicle stages but differ substantially in form and function at their adult stage. We sequenced and analyzed RNA populations present in mouse and chick during the early stages of embryonic telencephalon to understand conserved and lineage-specific developmental differences. We found approximately 3,000 genes that orchestrate telencephalon development. Many chromatin-associated epigenetic and transcription regulators were highly expressed in both species and some showed species-specific expression dynamics. Interestingly, previous studies associated them to autism, intellectual disabilities, and mental retardation supporting a causal link between their impaired functions during telencephalon development and brain dysfunction. Most striking was the finding that conserved up-regulated genes were differentially enriched in ontologies related to development or functions of the adult brain. Moreover, a differential enrichment of distinct repertoires of transcription factor binding motifs in their upstream promoter regions suggest a species-speci...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research

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BACKGROUND CONTEXT: Despite its potential to cause serious and life-long disability or death, population-based data on traumatic spinal injury in pediatric populations is scarce. PURPOSE: To quantify and describe the incidence and cost of hospitali...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Falls can lead to severe health loss including death. Past research has shown that falls are an important cause of death and disability worldwide. The Global Burden of Disease Study 2017 (GBD 2017) provides a comprehensive assessment of morbidi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: The Mangled Extremity Severity Score is a decision-making tool for limb amputation after trauma. The Disabilities of the Arm, Shoulder and Hand questionnaire was developed to quantify posttraumatic functional deficits of the upper extremity. Th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Publication date: Available online 17 January 2020Source: Sport Management ReviewAuthor(s): Jacqueline Martins Patatas, Veerle De Bosscher, Inge Derom, Jens De RyckeAbstractThe way disability is understood and positioned by key stakeholders informs how policies are implemented in the development of pathways to sporting excellence of an athlete with a disability. In this paper, the authors seek to identify which sports policy factors and stakeholders influence the development of athletic career pathways in Paralympic sport (i.e., attraction, retention, competition, talent identification and development, elite, and retiremen...
Source: Sport Management Review - Category: Sports Medicine Source Type: research
ConclusionsA nomenclature of 54 actions in Rheumatology was compiled. Biopsies (bone, sural nerve, synovial), inpatient visits, visits to the patient's home, infiltrations in children, and the preparation of the expert report were identified as the most complex actions. Musculoskeletal ultrasound is twice as complex as subsequent visits, capillaroscopy or bone densitometry.ResumenIntroducciónUna misión de la Sociedad Española de Reumatología es aportar las herramientas necesarias para alcanzar la excelencia asistencial. En la actualidad no existe una referencia que cuantifique la complejidad de ...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: Available online 17 January 2020Source: NeuroImage: ClinicalAuthor(s): Sukrit Gupta, Jagath C. Rajapakse, Roy E. WelschAbstractFunctional modules in the human brain support its drive for specialization whereas brain hubs act as focal points for information integration. Brain hubs are brain regions that have a large number of both within and between module connections. We argue that weak connections in brain functional networks lead to misclassification of brain regions as hubs. In order to resolve this, we propose a new measure called ambivert degree that considers the node’s degree as well as conne...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 17 January 2020Source: NeuroImage: ClinicalAuthor(s): Mladen Rakić, Mariano Cabezas, Kaisar Kushibar, Arnau Oliver, Xavier LladóAbstractAutism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detection of common patterns in autism subjects versus typical controls for classification purposes. In this work, we propose a method for t...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This week’s Psychology Around the Net explores how anxiety looks in children, how managers can work with employees dealing with depression, why young girls are struggling more with mental health issues than their male counterparts, a new bill that would make mental health a priority for first responders, and more.     Anxiety is Different for Kids: Do you have a child who struggles with anxiety? Would you even recognize it? According to the author, anxiety disorders in children can manifest in a variety of ways, and kids typically don’t display symptoms in the same way that adults do. Michigan-based ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Children and Teens Depression Disorders General Mental Health and Wellness Psychology Psychology Around the Net Research Students Trauma Childhood Anxiety Childhood Trauma First Responders girls' mental health Source Type: blogs
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Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
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