Validating faster DENSE measurements of cardiac-induced brain tissue expansion as a potential tool for investigating cerebral microvascular pulsations

This study aims, first, to validate a retrospectively-gated implementation of the DENSE method for assessing brain tissue pulsations as a physiological marker, and second, to use the acquired measurements to explore intracranial volume dynamics. We acquired repeated measurements of cerebral volumetric strain in 8 healthy subjects, and internally validated these measurements by comparing them to spinal CSF stroke volumes obtained in the same scan session.Peak volumetric strain was found to be highly repeatable between scan sessions. First/second measured peak volumetric strains were: (6.4 ± 1.7)x10−4/(6.7 ± 1.6)x10−4 for whole brain, (9.5 ± 2.5)x10−4/(9.6 ± 2.4)x10−4 for grey matter, and (4.4 ± 1.7)x10−4/(4.1 ± 0.8)x10−4 for white matter. Grey matter showed significantly higher peak strain (p 
Source: NeuroImage - Category: Neuroscience Source Type: research

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In recent years, mediation analysis has become a popular means to identify and quantify pathways linking an exposure to an outcome, thereby elucidating how a particular exposure contributes to the occurrence of a specific outcome. When a mediator is a modifiable risk factor, this opens up new opportunities for interventions to block (part) of the exposure`s effect on the outcome. Recent examples in Scandinavian Journal of Work Environment Health have addressed the mediating effect of wellbeing on the association between type of office and job satisfaction (1) and examined whether workplace social capital contributes to the...
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Editorial Source Type: research
AbstractPositron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical characteristics of PET tracers may help uncover the pathophysiological consequences of cardiac arrest (CA) and ischemic stroke, which include cerebral ischemia and reperfusion, depletion of oxygen and glucose, and neuroinflammation. PubMed was searched for studies of the application of PET for “cardiac arrest,” “ischemic stroke,” and “targeted temperature management.” Available studies were included and classified according to the bioche...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Tel-Aviv based AI company Aidoc received FDA clearance for tool that spots strokes on brain CT scans.
Source: Diagnostic Imaging - Category: Radiology Authors: Tags: CT Source Type: news
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: There is no justification for the use of reperfusion procedures in acute ischaemic stroke in the anterior circulation in patients with initially unfavourable multimodal computed tomography scores. PMID: 31908703 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
The 53rd edition of the Consumer Electronics Show (CES) is officially underway! With over  4,400 exhibiting companies from industries ranging from gaming to digital health showcasing their latest products and technologies, you might need some assistance to stay afloat in the flood of new announcements. Donning our rescue caps, The Medical Futurist team is coming to your aid! We’ve compiled the most exciting (and questionable) CES news relating to digital health that we’ve found at this year’s show. Let’s take a look! The Wows Every year at CES, companies come up with promising technologie...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine ces digital health Healthcare technology digital technology digital health companies digital health tech Source Type: blogs
Conclusions: Extending and deepening international performance analysis in order to cover patient pathways, including primary care and social services, is very useful for benchmarking activities when focusing on diseases affecting older people. PMID: 31916496 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
Conclusions: Easily conducted motor tests can be useful for early prediction of arm recovery. The added value of this study is the prediction of two levels of a favorable functional outcome from simple motor tests. This knowledge can be used in the development of prognostic models feasible in regular clinical settings, inform patient selection and stratification in future trials, and guide clinicians in the selection of individualized training strategies for improving arm functioning after stroke.Clinical Trial Registration:ClinicalTrials.gov: NCT02250365, NCT01115348.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Zhang HT, Chen LH, Xu RX Abstract BACKGROUND This case series study evaluated the outcome and effect of portable 3D-head computed tomography (CT, MCT-I, 16 rows mobile CT made in China) navigation-guided key-hole microsurgery for supratentorial hypertensive hematomas. MATERIAL AND METHODS Thirty-five consecutive unconscious patients with a significant volume of hypertensive intracranial hemorrhages (HICH) were treated with 3D image-guided key-hole microsurgery, and the clinical features were summarized. Preoperative and postoperative hematoma volumes and reduction in midline shifts were calculated and reco...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusions and significance: The English version of the OGQ was found to be a feasible instrument for identifying occupational gaps following mild stroke and may be suitable to support research and clinical practice with this population. PMID: 31906780 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
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