Is there a clinical role for Frozen Section Analysis during partial nephrectomy? A multicenter experience over 10 years.
Is there a clinical role for Frozen Section Analysis during partial nephrectomy? A multicenter experience over 10 years. Minerva Urol Nefrol. 2019 Dec 11;: Authors: Bozzini G, Seveso M, Romero Otero J, Osmolorskij B, Garcia Cruz E, Margreiter M, Verze P, Besana U, Buizza C Abstract BACKGROUND: Frozen section analysis (FSA) is frequently performed during partial nephrectomy (PN). We investigate the utility of intraoperative FSA by evaluating its impact on final surgical margin (SM) status. METHODS: Between January 1995 and December 2005 we prospectively analysed a series of patients who were treated with open PN for Renal Cell Carcinoma. During PN each patient underwent a FSA on renal parenchyma distal margin . If FSA was positive for infiltration a deeper excision was performed till obtaining a negative FSA. SM outcome of the FSA was compared with the final pathology report. We analyzed the recurrence-free survival (RFS) and cost analysis on the FSA performed. RESULTS: 373 patients were enrolled. FSA was performed in all the patients considered for PN. 15 patients had a conversion to radical nephrectomy. Positive SMs at the definitive pathological outcome were found in 36 patients (9.6%). FSA was positive in 8 patients (2.1%). In that 8 cases after a deeper excision the definitive pathological outcome on SM was still positive in 2 cases. FSA revealed just 14.3% of the positive SM. Patients with positive SM had a worse follow up considering RFS(p
CONCLUSIONS: Chromophobe renal cell carcinomashowed a greater tendency to metastasize, so requires asurveillance protocol based on the risk of recurrence. PMID: 31950927 [PubMed - in process]
ConclusionMPVLR is an easily obtainable prognostic marker for overall survival in nonmetastatic ccRCC patients treated with nephrectomy.
e Rha Cho Ham The molecular characteristics of early-stage clear cell renal cell carcinomas (ccRCCs) measuring ≤7 cm associated with poor clinical outcomes remain poorly understood. Here, we sought to validate genes associated with ccRCC progression and identify candidate genes to predict ccRCC aggressiveness. From among 1069 nephrectomies performed on patients, RNA sequencing was performed for 12 ccRCC patients with aggressive characteristics and matched pairs of 12 ccRCC patients without aggressive characteristics. Using a prospective cohort (ClinicalTrials.gov Identifier: NCT03694912), the expression...
Conclusion: Our study demonstrates the potential of CEUS in the differentiation of bland and tumor thrombus of the IVC in patients with RCC. Since CEUS is an effective, inexpensive, and non-invasive method, it could be a reliable tool in the evaluation of IVC thrombus in patients with RCC.
Publication date: Available online 9 January 2020Source: Urology Case ReportsAuthor(s): Hannah Morris, Brayden March, Warick Delprado, Nicholas McLeodAbstractAngiomyolipoma (AML) is a benign renal tumour composed of fat, smooth muscle and blood vessels. Radiologic evidence of macroscopic fat within a solid renal lesion on computed tomography was historically thought to be pathognomonic for this condition. Herein, we report a case of an incidental solid renal cell mass with multiple foci of intra-tumoral fat, which was shown to be a clear cell renal cell carcinoma (RCC) at nephrectomy. Macroscopic fat within solid renal les...
CONCLUSIONS: Tumor stage and its substages represent extremely important determinants of prognosis after lengthy event-free follow-up. The recorded observations have critical importance for physicians regarding patient follow-up and counseling. PMID: 31910387 [PubMed - in process]
A 56-year-old man presented with intermittent epistaxis. Nasopharyngoscope revealed a hemorrhagic mass occupying the left nasal cavity. The patient had a history of renal clear cell carcinoma. 18F-FDG PET/CT was performed to evaluate the potential lesions systematically. PET/CT images showed low to moderate activity in the region of nasal cavity and paranasal sinuses. No abnormal uptake of 18F-FDG was observed in the rest of the body. Eventually, the mass was pathologically proved to be metastatic renal clear cell carcinoma.
In conclusion, the incidence of RCC metastasis to the vagina is extremely rare; but, in cases of vaginal bleeding or lesions we have to keep in mind the possibility of metastatic RCC.
Publication date: Available online 3 January 2020Source: European UrologyAuthor(s): Geraldine Pignot, Antoine Thiery-Vuillemin, Jochen Walz, Hervé Lang, Pierre Werle, Loïc Balssa, Lionnel Geoffrois, Louis Leblanc, Laurence Albigès, Vincenzo di Nunno, Karim Bensalah, Sylvain Ladoire, Gwenaelle Gravis, Philippe Barthélémy
We report the case of a 15-year-old girl presenting with distended abdomen, left flank pain, and a history of weight loss. Computed tomography showed a large tumor involving the left kidney that was initially diagnosed as renal cell carcinoma. She underwent exploratory open laparotomy and left radical nephrectomy followed by chemotherapy and showed good response. Histology of the resected tumor revealed features of Ewing's sarcoma of the kidney which was confirmed by molecular studies. This disease is rare, particularly in the pediatric population, and this report will help better understand the potential disease course an...