Uptake pattern of 68GaGa-DOTA-NOC in tissues: implications for inflammatory diseases.

CONCLUSIONS: Tissues in which lymphocytic infiltration may occur show that SUVmax is tissue-dependent. Within tissue variability, an SUVmax greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition. PMID: 31833738 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

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Abstract Purpose: To evaluate quality of life in patients with established rheumatoid arthritis (RA) and identify the factors that negatively affect it. Methods: This was a cross-sectional study with patients with established RA from a rheumatology center in Ecuador. The RA Quality of Life (RAQoL) questionnaire was used to assess QoL and the Health Assessment Questionnaire - disability index (HAQ-DI) questionnaire for functional capacity. In addition, demographics, clinical characteristics, and markers of disease activity were included. Data were analyzed using SPSS 22. Results: Of 186 patients, 89.8% we...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Open Access Rheumatol Source Type: research
Total external ophthalmoplegia: First clinical manifestation of Sjögren's syndrome. Strabismus. 2019 Sep 06;:1-5 Authors: Singh A, Mahesh M, Agrawal A, Kumar N, Verma R, Mittal SK, Kumar B Abstract Sjögren's syndrome (SS) is an autoimmune disease causing destruction of the exocrine glands secondary to lymphocytic infiltration. Common clinical symptoms of SS are xerostomia, xerophthalmia, myalgia, arthritis, and vasculitis. Neurological symptoms may precede the diagnosis of SS by up to 2 years in about 80% of patients. A 28-year-old female presented to us with complaints of horizontal and vert...
Source: Strabismus - Category: Research Tags: Strabismus Source Type: research
Semin Respir Crit Care Med 2019; 40: 235-254 DOI: 10.1055/s-0039-1688448Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features o...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
ConclusionEven though exocrinopathy is the hallmark of Sj ögren’s syndrome, systemic symptoms are observed in one-third of patients. There is an urgent need to better characterize the mechanisms underlying different disease phenotypes and to perform randomized controlled trials in order to provide tailored and evidence-based treatment for primary Sjögr en’s syndrome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Present and novel biologic drugs in primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 Apr 26; Authors: Fasano S, Isenberg DA Abstract Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by xerostomia and xerophthalmia. In at least one-third of patients, the disease may be complicated by extraglandular involvement. Due to the lack of evidence-based recommendations, current therapeutic options for pSS are mainly empirical, often reflecting their use in other autoimmune diseases. Nevertheless, recent advances in the understanding of pathogenic pathways in pSS encou...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
The objective of this study was to compare resting and stimulated sialometry methods and analyze their association with the intensity of xerostomia.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Oral and Maxillofacial Pathology Source Type: research
Publication date: Available online 10 August 2018Source: Autoimmunity ReviewsAuthor(s): Konstantia Psianou, Ioannis Panagoulias, Anastasios D. Papanastasiou, Anne-Lise de Lastic, Maria Rodi, Panagiota I. Spantidea, Søren E. Degn, Panagiotis Georgiou, Athanasia MouzakiAbstractSjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and lacrimal glands, and deposition of several types of autoantibodies, mainly anti-SS-A (anti-Ro) and anti-SS-B (anti-La), lead to chronic inflammation, wi...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Discussion Sjögren Syndrome (SS) is named for Swedish ophthalmologist Henrik Sjögren who published a case series in 1933 describing patients with dry eyes and arthritis. SS is a “chronic autoimmune inflammatory exocrinopathy” that is characterized by lymphocytic infiltration of the lacrimal and salivary glands and has various degrees of systematic involvement. Keratoconjunctivitis sicca and xerostomia are the main clinical symptoms. Sicca is a Latin word meaning dry. Dryness of the eyes and mouth without evidence of autoimmune disease is called Sicca syndrome or Sicca complex. SS can be primary or se...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Clinical Image Source Type: research
ConclusionBecause there seem to be a high prevalence of xerostomia in patients with rheumatoid arthritis, screening in such population is highly recommended. Therefore, educational programs and/or workshops should be encouraged among healthcare providers to prevent worsening of oral health‐related quality of life.
Source: Oral Diseases - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
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