Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice

Publication date: 15 January 2020Source: Life Sciences, Volume 241Author(s): Ekaterina Veniaminova, Margarita Oplatchikova, Lucien Bettendorff, Elena Kotenkova, Alexander Lysko, Ekaterina Vasilevskaya, Allan V. Kalueff, Liliya Fedulova, Aleksei Umriukhin, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana StrekalovaAbstractAimsThe high sugar and lipid content of the Western diet (WD) is associated with metabolic dysfunction, non-alcoholic steatohepatitis, and it is an established risk factor for neuropsychiatric disorders. Our previous studies reported negative effects of the WD on rodent emotionality, impulsivity, and sociability in adulthood. Here, we investigated the effect of the WD on motor coordination, novelty recognition, and affective behavior in mice as well as molecular and cellular endpoints in brain and peripheral tissues.Main methodsFemale C57BL/6 J mice were fed the WD for three weeks and were investigated for glucose tolerance, insulin resistance, liver steatosis, and changes in motor coordination, object recognition, and despair behavior in the swim test. Lipids and liver injury markers, including aspartate-transaminase, alanine-transaminase and urea were measured in blood. Serotonin transporter (SERT) expression, the density of Iba1-positive cells and concentration of malondialdehyde were measured in brain.Key findingsWD-fed mice exhibited impaired glucose tolerance and insulin resistance, a loss of motor coordination, deficits in novel object exploration an...
Source: Life Sciences - Category: Biology Source Type: research

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Conclusion: Fun seeking on the BAS and frustration intolerance should be considered as targets in prevention and intervention programs for IA among adolescents with ADHD.IntroductionThe negative effects of internet addiction (IA) have become a concern in the past decades. IA is characterized by persistent internet use despite negative consequences, loss of control, preoccupation with internet use, increasing amounts of time spent online, and withdrawal symptoms (1). Internet gaming disorders are listed in the “Conditions for Further Study” section in the Fifth Edition of Diagnostic and Statistical Manual of Men...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we explore shared epigenetic mechanisms of the association between mtDNA content and insulin levels, supporting the developmental origins of this link. First, the association between cord blood insulin and mtDNA content in 882 newborns of the ENVIRONAGE birth cohort was assessed. Cord blood mtDNA content was established via qPCR, while cord blood levels of insulin were determined using electrochemiluminescence immunoassays. Then the cord blood DNA methylome and transcriptome were determined in 179 newborns, using the human 450K methylation Illumina and Agilent Whole Human Genome 8 × 60 K microarrays, r...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
What is a Crystal Meth Addiction? Crystal meth is the name for the street drug crystal methamphetamine. Crystal meth can also be known as ice or glass, and it can be either snorted, smoked or dissolved and injected. It is a very strong and highly addictive drug. It affects the central nervous system, and crystal meth addiction has dangerous life-threatening effects. Understanding Crystal Meth Crystal meth is a man-made stimulant drug that has no legal use. It is made with methamphetamine, pseudoephedrine and a combination of other chemicals. Methamphetamine has been around for a long time, originally created to keep soldie...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Drug Treatment Methamphetamines Substance Abuse crystal methamphetamine meth addiction Source Type: blogs
CONCLUSIONS: Long-term associations of childhood ADHD with adverse physical health and socioeconomic outcomes underscore the need for early intervention. Young adult ADHD showed stronger associations with poorer mental health, substance misuse and psychosocial outcomes, emphasising the importance of identifying and treating adults with ADHD. The Study in Context: Neurofeedback or medication to treat ADHD? What are cognitive abilities and how to boost them? Rates of ADHD diagnosis and medication treatment continue to increase substantially
Source: SharpBrains - Category: Neuroscience Authors: Tags: Attention and ADD/ADHD Education & Lifelong Learning Health & Wellness ADHD symptopms attention deficit hyperactivity disorder Genetics mental health problems psychiatry Source Type: blogs
New treatment using ground peanut protein could be approved next year Related items fromOnMedica Parents urged to promote 'alcohol-free childhood' Kids with ADHD should be placed on a special diet CAM can be lethal to children Poorest Scottish kids do the least exercise Local authorities urged to develop innovative plans against childhood obesity
Source: OnMedica Latest News - Category: UK Health Source Type: news
Follow me on Twitter @RobShmerling Ever wonder what other people are wondering about? I know I do. So, here are the top 10 health searches in Google for 2017. And just so you don’t have to look each one up, I’ve provided a brief answer. You’re welcome. 1.  What causes hiccups? I was surprised this one made it to the top 10 list of health searches. Maybe this search is common because hiccups are as mysterious as they are universal. I’ve written about hiccups before, but let’s just say the cause in any individual person is rarely known or knowable. Then again, the reason hiccups stop is als...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
Location:College of Medicine, Veterinary and Life Sciences, Glasgow, United KingdomSalary:A stipend of£14,553& tuition feesClosing Date:10 January 2018 Supervisors: Dr Michelle Bellingham, Dr Amanda Drake, Prof Paul A. FowlerProject details: The fetal environment plays a key role in programming normal brain development in the womb. Maternal lifestyle factors such as malnutrition, obesity, smoking and alcohol consumption are associated with altered brain development and behaviour, including attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and anxiety disorders in the o...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusion: The findings of this study suggest that gender specific intervention programs may be need to help eating behaviour in children with ADHD and overweight. PMID: 29209385 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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