Rapid and selective diagnose of Sarcosine in urine samples as prostate cancer biomarker by mesoporous imprinted polymeric nanobeads modified electrode
Publication date: Available online 9 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Omid Sheydaei, Habibollah Khajehsharifi, Hamid Reza RajabiAbstractThe presence of sarcosine (SAR) in the human urine was recently suggested as a promising biomarker for prostate cancer (PCa) diagnostics. In this work, we have developed the electrochemical methods for selective determination of sarcosine (SAR) in urine samples, based on the modification of the carbon paste electrode (CPE) using uniform nano-scaled molecularly imprinted polymer (MIP). The uniform MIP nanobeads were prepared by a simple sol-gel method, using methacrylic acid as a functional monomer in a mixture of acetonitrile/water, as porogen. The usual problems related to the imprinting of the biologically polar compounds, especially; amino acids were solved by performance the present approach. After characterization, the as-synthesized MIP particles were used as chemical modifier for the construction of a modified CPE. The electrochemical behaviors and quantitative analysis of SAR were evaluated on MIP@CPE by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), respectively. The modified sensor exhibits reproducible voltammetric responses with a relative standard deviation of 2.1% and a highly selective affinity toward SAR in the presence of other co-existing and/or possible interferes. Under the optimized conditions, the peak current was found to be proportional to SAR concentration over a rang...
Publication date: Available online 16 January 2020Source: Molecular Aspects of MedicineAuthor(s): Delila Gasi Tandefelt, Johann de BonoAbstractOnly in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in indivi...
Prostate Cancer and Prostatic Diseases, Published online: 17 January 2020; doi:10.1038/s41391-020-0205-7A noninferiority within-person study comparing the accuracy of transperineal to transrectal MRI–US fusion biopsy for prostate-cancer detection
ConclusionIn this series of patients, we have shown that metastatic LNs can be safely treated with image-guided CA. Caution should be paid, and additional measures should be taken when treating LNs near thermal-sensible structures.
A new analysis provides estimates of bowel, bladder, and sexual function through five years following contemporary treatments for localized prostate cancer, which may help men clarify expectations and make more informed treatment choices, the research team says.Reuters Health Information
Behavioral intervention had no impact on time to progression among men with early - stage disease
Conclusion 68Ga-PSMA PET-CT allows accurate detection of lymphnodal metastases in patients with intermediate-risk and high-risk prostate cancer prior to definitive surgical treatment. It performed better than mp-MRI in a subset of patients.
Conclusion Our study demonstrated that visual report of [18F]FCH PET/CT was very reproducible and that the repeatability limits of SUVmax was similar to those of other PET radiotracers. An SUVmax difference of more than 40% should be considered as representing a treatment response effect. Change of SUVmax during the acquisition time varied and should not be considered as an interpretation criterion.
Authors: Wu Z, Xu X, Dai L, Wang Y, Yang B, Zhao H, Lou C Abstract Eupalinolide J (EJ) is a new sesquiterpene lactone isolated from Eupatorium lindleyanum DC. In the present study, we investigated the anti-cancer activity of EJ on cell proliferation in human prostate cancer cells. The MTT results indicated that EJ showed marked anti-proliferative activity in PC-3 and DU-145 cells in a dose- and time-dependent manner. DAPI staining analysis demonstrated that this effect was mediated by induction of cell apoptosis. Flow cytometric analysis indicated a significant increase in apoptotic cells, cell cycle arrest at G0/G...
This sixth annual report presents the results for patients diagnosed with prostate cancer between 1st April 2017 and 31st March 2018 in England and Wales. It is accompanied by provider results and an infographic.