Crosstalk between transforming growth factor- β3 and microRNA-29c in leiomyoma: are we stepping forward?

Uterine fibroids (UFs) are benign monoclonal neoplasms, representing the most common solid tumor of the female genital tract in reproductive-aged women. Despite the incidence being generally high worldwide (70% –80% in women by the age of 50 years), UFs affect ≤80% of women in some particular populations (African-American women). Furthermore, UFs are relative common in pregnancy and might negatively influence its outcomes (1). Uterine fibroids are generally asymptomatic; however, when symptoms occur, they might impair normal functioning and affect quality of life, most widely causing abnormal uterine bleeding and iron deficiency anemia, abdominal and pelvic pain, and compression to the surrounding organs thus urologic and gastrointestinal symptoms.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research