Association between obesity and mortality in adult patients receiving invasive mechanical ventilation: A systematic review and meta-analysis

ConclusionNo relationship was found between the subgroup of obese adult patients receiving IMV and the mortality variable in the ICU.ResumenObjetivoEvaluar si existe asociación entre obesidad y mortalidad en la Unidad de Cuidados Intensivos (UCI) en pacientes adultos que reciben ventilación mecánica invasiva.DiseñoRevisión sistemática con metaanálisis.ÁmbitoUCI.Fuente de datosSe realizó una búsqueda en las bases de datos MEDLINE, Cochrane Library, CINAHL y Global Health sin restricción de lenguaje, hasta el 21 de febrero del año 2017.Selección de estudiosSe incluyeron estudios que informaron mortalidad en UCI en pacientes obesos versus no obesos que recibieron VMI.Variables principalMortalidad en UCI.ResultadosSe hallaron 2.163 artículos, de los cuales se incluyeron 14 estudios. No se encontraron diferencias estadísticamente significativas entre los pacientes obesos y no obesos respecto a la variable mortalidad en UCI (odds ratio: 0,94; intervalo de confianza del 95%: 0,81-1,10; p = 0,45).ConclusiónNo se halló relación entre el subgrupo de pacientes adultos obesos que reciben VMI y la variable mortalidad en UCI.
Source: Medicina Intensiva - Category: Intensive Care Source Type: research

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Publication date: Available online 25 January 2020Source: Preventive MedicineAuthor(s): Ying Lau, Daniel Guang Hui Chee, Xue Ping Chow, Ling Jie Cheng, Suei Nee WongAbstractGiven that many existing electronic health (eHealth) interventions with a general approach have limited effects, a personalised approach is necessary. We aimed to evaluate the effectiveness of personalised eHealth interventions in reducing body weight and identify the effective key features of such interventions. We searched seven databases for randomised controlled trials (RCTs) from inception until September 6, 2018. Of the 26,733 records identified, ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Steven M. Dean, Elizabeth Valenti, Karen Hock, Julie Leffler, Amy Compston, William T. AbrahamAbstractBackgroundLower extremity lymphedema is frequently encountered in the vascular clinic. Established dogma purports that cancer is the most common cause of lower extremity lymphedema in Western countries, whereas chronic venous insufficiency (CVI) is often overlooked as a potential cause. Moreover, lymphedema is typically ascribed to a single cause, yet multiple causes can coexist.MethodsA 3-year re...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
ConclusionsIn conclusion, we identified a genetic regulator of spontaneous lipolysis, and provide evidence for HIF3A as a novel key regulator of lipolysis in subcutaneous adipoctyes as the mechanism through which the locus is influencing adipose tissue biology.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
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Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 25 January 2020Source: Life SciencesAuthor(s): Wei-Wei Sun, Tao ShangGuan, Ping Zhu, Hua-Kang Li, Min Jiang, Pan Yang, Lin-Yu Li, Zhi-Hui ZhangAbstractAimsNPY-Y1R plays an important role in dietary regulation. Although germline knockdown of NPY-Y1R in mice alleviates high-fat-diet-induced obesity and increases CPT1α levels in the liver, the role of the Y1 receptor in specific tissues has not been studied.Main methodsMCD diet is the most widely used method to establish a model of lean NASH in a short time. We therefore evaluated the role of liver NPY-Y1R in NASH progression.Key findi...
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