Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays.

Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays. Clin Microbiol Rev. 2019 Dec 18;33(1): Authors: Voordouw B, Rockx B, Jaenisch T, Fraaij P, Mayaud P, Vossen A, Koopmans M Abstract SUMMARYInfections during pregnancy that may cause congenital abnormalities have been recognized for decades, but their diagnosis is challenging. This was again illustrated with the emergence of Zika virus (ZIKV), highlighting the inherent difficulties in estimating the extent of pre- and postnatal ZIKV complications because of the difficulties in establishing definitive diagnoses. We reviewed the epidemiology, infection kinetics, and diagnostic methods used for Toxoplasma gondii, parvovirus B19, rubella virus, and cytomegalovirus (TORCH) infections and compared the results with current knowledge of ZIKV diagnostic assays to provide a basis for the inclusion of ZIKV in the TORCH complex evaluations. Similarities between TORCH pathogens and ZIKV support inclusion of ZIKV as an emerging TORCH infection. Our review evaluates the diagnostic performance of various TORCH diagnostic assays for maternal screening, fetal screening, and neonatal screening. We show that the sensitivity, specificity, and positive and negative predictive value of TORCH complex pathogens are widely variable, stressing the importance of confirmatory testing and the need for novel techniques for earlier and accurate dia...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research

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Publication date: Available online 16 January 2020Source: Cell ReportsAuthor(s): Shaobo Wang, Qiong Zhang, Shashi Kant Tiwari, Gianluigi Lichinchi, Edwin H. Yau, Hui Hui, Wanyu Li, Frank Furnari, Tariq M. RanaSummaryWe perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is correlated with ZIKV susceptibility in various cells and tropism in developing human cerebral cortex. A blocking antibody against integrin αvβ5, but not αvβ3, efficiently inhibits ZIKV infection. ZI...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Blackmore TK, Bloomfield M, Burge S, Low K, Dzhelali M, Nesdale A PMID: 31945050 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ05225A, Paper Mayank, Deepak Kumar, Navneet Kaur, Rajanish Giri, Narinder Singh Competitive NTPase inhibition and the potential binding to the RNA binding pocket of Zika NS3-helicase were observed using biscoumarin derivatives. The SAR was established, and MN-9 and MN-10 were identified as potent anti-Zika leads. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsReceiving the birth dose is positively associated with up-to-date status later in childhood, highlighting the importance of starting vaccination early. The association is insensitive to confounding by factors observed in National Immunization Survey-Child, but investigation of unobserved factors such as vaccine hesitancy could provide critical information to guide intervention strategy.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Suoh M, Tamori A, Amano-Teranishi Y, Nakai T, Enomoto M, Kawasaki Y, Kioka K, Kawada N Abstract The appropriate management of hepatitis B virus (HBV) infection during pregnancy has not been established in Japan. We herein report five HBV-infected pregnant Japanese women who received tenofovir disoproxil fumarate (TDF). Two of them had been born after the introduction of nationwide immunoprophylaxis and were vertically infected with HBV, highlighting the need to address mother-to-child transmission further. In both entecavir-experienced and nucleoside/nucleotide analog-naïve mothers, TDF suppressed HBV...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 16 January 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Gabriela M. Marques, Diego Z. Nascimento, Daisson J. Trevisol, Betine P.M. IserAbstractTo systematically identify studies about the assessment of pregnant women’s expectations, using measuring instruments. An online search was made of Medline/PubMed, SciELO, Google Scholar, CAPES and LILACS databases in national and international publications from their first indexation until December 2018, using words associated with expectations during pregnancy. This review included observatio...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
I'm a MS4, pregnant w/ due date of June 28th 2019... few days prior to residency start date. I am already near the end of my interview trail so I'm planning on matching this year to IM. I've done my searches through the thread about the options w/FMLA, sick days etc. (Since I definitely would not have worked a full year w/ my new employer, I am not covered under FMLA) However it seems the fact that I can't start residency on July 1st complicates the picture quite a bit. Residencies can... Pregnant &can't start new residency on July 1st
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: General Residency Issues Source Type: forums
Credit: UN WomenBy Thalif DeenUNITED NATIONS, Jan 17 2020 (IPS) The United States and 18 other UN member states have come under fire for denying a woman’s legitimate right to “bodily autonomy”—the right to self-governance over one’s own body without coercion or external pressure. The Executive Director of Women’s March Global, Uma Mishra-Newbery, told IPS the United Nations has worked towards progress in fighting for women’s rights. But many countries on the Human Rights Council continue to negotiate women’s human rights off the table, she pointed out. In Sept 2019, she sa...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Gender Global Headlines Health Human Rights IPS UN: Inside the Glasshouse TerraViva United Nations Women's Health Source Type: news
This study included more recent evidence compared to the previous one. The Bradford-Hill Viewpoints are used in public health to determine causation of diseases.11 Systematic application of the viewpoints can assist with analysing a possible causal relationship. Additional studies to assess the risk of microcephaly in affected pregnant mothers are ongoing.12 In this study we applied the Bradford-Hill viewpoints to investigate the association between Zika virus and Microcephaly. Method Using the Bradford Hills nine viewpoints we analysed data from a 2013 outbreak in French Polynesia and the 2015 Brazilian outbreak to esta...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
This study included more recent evidence compared to the previous one. The Bradford-Hill Viewpoints are used in public health to determine causation of diseases.11 Systematic application of the viewpoints can assist with analysing a possible causal relationship. Additional studies to assess the risk of microcephaly in affected pregnant mothers are ongoing.12 In this study we applied the Bradford-Hill viewpoints to investigate the association between Zika virus and Microcephaly. Method Using the Bradford Hills nine viewpoints we analysed data from a 2013 outbreak in French Polynesia and the 2015 Brazilian outbreak to esta...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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