Genome-wide methylation and expression profiling identify methylation-associated genes in colorectal cancer

Epigenomics, Ahead of Print.
Source: Future Medicine: Epigenomics - Category: Genetics & Stem Cells Authors: Source Type: research

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CONCLUSIONS BORG promotes the development of chemoresistance of CRC cells to carboplatin. PMID: 31937750 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Nguyen HT, Tran DH, Ngo QD, Pham HT, Tran TT, Tran VU, Pham TN, Le TK, Le NT, Nguyen NM, Vo BT, Nguyen LT, Nguyen TV, Bui QTN, Nguyen HN, Le LGH, Do DM, Do TT, Truong Dinh K, Phan MD, Tran LS, Giang H, Nguyen HN Abstract The identification and quantification of actionable mutations are critical for guiding targeted therapy and monitoring drug response in colorectal cancer. Liquid biopsy (LB) based on plasma cell-free DNA analysis has emerged as a non-invasive approach with many clinical advantages over conventional tissue sampling. Here, we developed a LB protocol using ultra-deep massive parallel sequenci...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Meet Molly, Ginger and Replika – some of your new chatbot friends aiming to make your life better. In the last years, smart algorithm-powered, text or voice-based interfaces have multiplied, and they are also taking their place in healthcare. The Medical Futurist believes they will ease the burden on doctors in primary care and help patients learn to take care of their health responsibly. Do you want to try one? Check out the following health chatbots! The age of talking algorithms is here In 2018, Google stunned the world with the latest feature of the Google Assistant, Duplex, which was able to make an appoint...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Healthcare Design AI chatbot digital health Innovation List medical Personalized medicine technology chatbots health chatbot Source Type: blogs
Although researchers determined which regimen was preferred among physicians in treating metastatic colorectal cancer, they found that shared decision-making should include observation as an acceptable option.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Conclusion: A combined evaluation of Hb, NLR, and MPV values in patients with CWT in abdominal CT examination may contribute to the separation of benign and malignant pathologies. PMID: 31933628 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: Li C, Zuo D, Liu T, Yin L, Li C, Wang L Abstract Objective: To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics. Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Conclusions: Our data support that loss of Ffar2 signaling potentiates tumorigenesis via a “two-hit” model, first by gut barrier breach and then by immune cell dysfunction. Our work supports that altering Ffar2 signaling or neutralizing IL-27 represent potential immunotherapy CRC treatment strategies.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsNo significant difference was observed in IR rates between VATS and open surgery in the treatment of colorectal cancer lung metastases.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
ConclusionsSystematic reviews cited in NCCN guidelines for colon and rectal cancer are frequently at unclear or high risk of bias and do not report key systematic review items that are important for the critical appraisal of results.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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