Validation of the analytical irradiator model and Monte Carlo dose engine in the small animal irradiation treatment planning system µ-RayStation 8B.

Validation of the analytical irradiator model and Monte Carlo dose engine in the small animal irradiation treatment planning system µ-RayStation 8B.
Phys Med Biol. 2019 Dec 12;:
Authors: Chiavassa S, Nilsson R, Clement-Colmou K, Potiron V, Delpon G, Traneus E
Abstract
Dose calculation in preclinical context with a clinical level of accuracy is a challenge due to the small animal scale and the medium photon energy range. In this work, we evaluate the effectiveness and accuracy of an analytical irradiator model combined with Monte Carlo (MC) calculations in the irradiated volume to calculate the dose delivered by a modern small animal irradiator. A model of the XRAD225Cx was created in µ-RayStation 8B, a preclinical treatment planning system, allowing arc and static beams for 7 cylindrical collimators. Calculations with the µ RayStation MC dose engine were compared with EBT3 measurements in water for all static beams and with a validated GATE model in water, heterogeneous media and a mouse CT. The GATE model is a complete MC representation of the XRAD225Cx. In water, µ-RayStation calculations, compared to GATE calculations and EBT3 measurements, agreed within a maximal error of 3.2% (mean absolute error of 0.6% and 0.8% respectively) and maximal distance-to-agreement (DTA) was 0.2mm at 50% of the central dose. For a 5mm static beam in heterogeneous media, the maximal absolute error between µ RayStation and GATE calculations was be...

Source: Physics in Medicine and Biology - December 11, 2019 Category: Physics Authors: Chiavassa S, Nilsson R, Clement-Colmou K, Potiron V, Delpon G, Traneus E Tags: Phys Med Biol Source Type: research