A case report of nivolumab-induced myasthenia gravis and myositis in a metastatic renal cell carcinoma patient

We present a 78-year-old male with renal cell carcinoma who developed myasthenia gravis complicated by myositis after nivolumab administration, which was verified by the presence of antibodies against the acetylcholine receptor. The initial symptom was posterior neck pain, and biochemical examination of blood showed elevated levels of hepatic enzymes and creatine phosphokinase. The level of antibody against the acetylcholine receptor increased 4.1-fold. His condition progressed rapidly resulting in respiratory failure 15 days after conservative therapy.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research

Related Links:

Abstract A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
This study aims to unveil the mechanisms underlying the pro-apoptotic effect of Cur-NLC on HepG2 cells. Evidence indicates that low expression of death receptors (DRs) on cancer cell membranes leads to attenuated apoptosis signaling. This study showed that Cur-NLC significantly increased total expression of DR5 protein while simultaneously upregulated cell membrane expression of DR5. Cur-NLC significantly increased caspase-8 and caspase-3 activities, accompanied by increased apoptosis. Furthermore, enhanced apoptosis was inhibited in the presence of a pan-caspase inhibitor, Z-VAD-FMK. Therefore, Cur-NLC induced activation ...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
From every indication of the text storm between reps, this year's NANS is the one **NOT** to miss. It's going to be the duck's nuts!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
This week's very cool case was donated by Dr. Mike Feely. We haven't had anything like this one before on the blog!The specimen below was submitted by a young woman who found this " worm " by her arm, right below her mouth, upon waking from a nap. She reported having abdominal pain with associated diarrhea for several weeks prior to presentation, but was otherwise healthy. After being in formalin:Histologic sections (H&E):Identification? Any additional information that you would like?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
A new study casts doubt on the popular notion that smoking weed or using CBD may help cancer patients cope with pain.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Researchers at the University of Israel assessed the sleep quality and levels of pain of 128 people over 50 being treated at a specialist clinic.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
OBJECTIVES: Alcohol for intercostal neuralgia may induce severe injection pain. Although nerve block provided partial pain relief, alcohol might be diluted, and the curative effect decreased when the local anesthetic and alcohol were given at the same point. Therefore, we observed the modified method for intercostal neuralgia, a Two-point method, in which the local anesthetic and alcohol were given at different sites. METHOD: Thirty patients diagnosed with intercostal neuralgia were divided into 2 groups: Single-point group and Two-point group. In the Single-point group, alcohol and local anesthetic were injected at the sa...
Source: Clinics - Category: General Medicine Source Type: research
CONCLUSION: Ultrasound could be as sensitive and specific as contrast-enhanced MRI for the diagnosis of subclinical synovitis and tenosynovitis.
Source: Clinics - Category: General Medicine Source Type: research
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractIntroductionWe compared the preoperative quality of life (QOL) of patients with carpal tunnel syndrome, lower extremity-, and para-lumbar entrapment syndrome, and the effect of surgery on their QOL.Patients and methodsWe prospectively enrolled 66 consecutive patients who underwent surgery for carpal tunnel syndrome (group 1,n = 23), lower extremity entrapment syndrome (group 2,n = 22), and para-lumbar entrapment syndrome (group 3,n = 21). Their pre- and postoperative overall health status was assessed on the Medical Outcomes Study Short-Form 36 Health Survey, v2 (SF-36).Res...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
More News: Cancer & Oncology | Carcinoma | Kidney Cancer | Myasthenia Gravis | Pain | Renal Cell Carcinoma | Respiratory Medicine | Urology & Nephrology