Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System

We propose that abnormalities of the pulmonary system contribute significantly to the exertional dyspnea and exercise intolerance observed in patients with chronic heart failure. Interventions designed to address the deleterious pulmonary manifestations of heart failure may, therefore, yield promising improvements in exercise tolerance in this population.
Source: Exercise and Sport Sciences Reviews - Category: Sports Medicine Tags: Articles Source Type: research

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Most people know about the damaging effects that binge drinking can bring to someone’s life. Loss of enjoyment of life, losing family relationships, financial and career struggles, homelessness, and legal consequences are just the tip of the iceberg. However, it can be more difficult to realize the long-term effect of binge drinking on the body, because you cannot always see it. Frequent binge drinking poses many dangerous health risks, and many of them can lead to death. Facts on Long-Term Effect of Binge Drinking on the Body For men, binge drinking is defined as consuming five or more drinks within about two hour...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol treatment alcohol treatment center binge binge drinking Source Type: blogs
Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.06
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Authors: Du Z, Xu W, Chen X, Xu D, Li Y, Zhang H, Gao L PMID: 31937077 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: Saritas T, Floege J Abstract Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therap...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
I'm still a medical student (IMG), but I can easily tell how good a doctor is in non-surgical specialties. I can simply look up what they are saying and see if it makes sense. When one of my teachers said "End diastolic volume decreases in systolic heart failure" and stuck with that assertion after I questioned it, I knew that I should stick to a textbook for instruction. I'm rewatching a cell phone video of a foot amputation we got to see and I'm wondering how "correct" the surgical... How can you tell if a surgeon is good?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Publication date: Available online 16 January 2020Source: Canadian Journal of CardiologyAuthor(s): Etsuo Iwata, Toru Kondo, Toshiaki Kato, Takahiro Okumura, Itsumure Nishiyama, Shingo Kazama, Toshikazu Ishihara, Sayano Kondo, Hiroaki Hiraiwa, Takuma Tsuda, Masanori Ito, Morihiko Aoyama, Daisuke Tanimura, Yoshifumi Awaji, Kazumasa Unno, Toyoaki MuroharaAbstractBackgroundDelirium is a common adverse event observed in patients admitted to an intensive care unit (ICU). However, the prognostic value of delirium and its determinants have not been thoroughly investigated in patients with acute heart failure (AHF).MethodsWe invest...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 15 January 2020Source: Canadian Journal of CardiologyAuthor(s): Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung ChangAbstractBackgroundTumor necrosis factor inhibitors (TNFi) improve joints outcomes and reduce cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). However, 20-45% of RA patients are TNFi poor responders and have a significantly higher risk of CV events. In these TNFi non-responders, the use of second-line biological agents to improve synovial outcomes is supported by clinical...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 15 January 2020Source: American Heart JournalAuthor(s): Sean van Diepen, Wayne Tymchak, Erin A. Bohula, Jeong-Gun Park, Lori B. Daniels, Nicholas Phreaner, Christopher F. Barnett, Benjamin B Kenigsberg, Andrew DeFilippis, Narayana Sarma Singam, Gregory W. Barsness, Jacob C. Jentzer, Bradley Ternus, David A. Morrow, Jason N. Katz, Critical Care Cardiology Trials Network InvestigatorsBackgroundThe prevalence of renal disease in cardiac intensive care units (CICUs) is increasing, but little is known about the utilization, concurrent therapies, and outcomes of patients requiring acute renal r...
Source: American Heart Journal - Category: Cardiology Source Type: research
Conclusion Discordance with stress myocardial blood flow in the corresponding flow territory was found in 32% of the fractional flow reserve-measurements. Patients with reduced stress myocardial blood flow but normal fractional flow reserve showed significantly reduced stress myocardial blood flow in all coronaries and a trend towards more cardiac adverse events.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Authors: Frey C, Koliopoulou AG, Montenont E, Tolley ND, Javan H, McKellar SH, Drakos SG, Selzman CH, Rondina MT Abstract Patients with heart failure (HF) and left ventricular assist devices (LVAD) have dysregulated thrombo-inflammatory responses, mediated in part by platelets. While studies of platelet activation have been undertaken in HF, changes in the platelet transcriptome in HF patients following mechanical unloading with an LVAD have not been investigated. We prospectively enrolled and longitudinally followed advanced HF patients (n = 32) for a mean of 57 months post-LVAD implantation. For co...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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