Protein interaction networks as starting points to identify novel antimicrobial drug targets.

Protein interaction networks as starting points to identify novel antimicrobial drug targets.
Curr Opin Microbiol. 2013 Aug 9;
Authors: Zoraghi R, Reiner NE
Abstract
Novel classes of antimicrobials are needed to address the challenge of multidrug-resistant bacteria. Current bacterial drug targets mainly consist of specific proteins or subsets of proteins without regard for either how these targets are integrated in cellular networks or how they may interact with host proteins. However, proteins rarely act in isolation, and the majority of biological processes are dependent on interactions with other proteins. Consequently, protein-protein interaction (PPI) networks offer a realm of unexplored potential for next-generation drug targets. In this review, we argue that the architecture of bacterial or host-pathogen protein interactomes can provide invaluable insights for the identification of novel antibacterial drug targets.
PMID: 23938265 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - August 9, 2013 Category: Microbiology Authors: Zoraghi R, Reiner NE Tags: Curr Opin Microbiol Source Type: research