Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats.

Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats. Chronobiol Int. 2019 Dec 13;:1-17 Authors: Tateishi N, Morita S, Yamazaki I, Okumura H, Kominami M, Akazawa S, Funaki A, Tomimori N, Rogi T, Shibata H, Shibata S Abstract Metabolism of lipids such as cholesterol and triglycerides has daily variations and is controlled by a circadian clock. Sesamin isomers, a mixture of sesamin and episesamin (SE), are types of lignans in sesame seed that have shown the improvement of lipid metabolism with various diseases in an animal model. We therefore tested whether the effects of SE on lipid metabolism are influenced by timing of administration. High-fat diet (HFD)-loaded rat was administered SE in the ZT13 or 14 (at the beginning of the active phase) or ZT23 or 22 (at the end of the active phase) every day for 7 or 28 days, and the effects on lipid metabolism were evaluated. The effects of SE were enhanced by duration-dependency: 28-day administration of SE strongly affected some parameters related to lipid metabolism, particularly cholesterol metabolism, as compared to 7-day administration. In particular, in 28-day administration, the analysis of serum and liver cholesterol levels revealed that SE administration decreases more effectively at the beginning of the active phase when compared to at the end of that. Furthermore, quantitative real-time polymerase chain reaction (QRT-PCR) and functiona...
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research