Chemical constituents from Schisandra sphenanthera and their cytotoxic activity.

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity.
Nat Prod Res. 2019 Dec 12;:1-10
Authors: Mai NT, Doan VV, Lan HTT, Anh BTM, Hoang NH, Tai BH, Nhiem NX, Yen PH, Park SJ, Seo Y, Namkung W, Kim SH, Kiem PV
Abstract
Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B (3) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.
PMID: 31829042 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 11, 2019 Category: Biochemistry Authors: Mai NT, Doan VV, Lan HTT, Anh BTM, Hoang NH, Tai BH, Nhiem NX, Yen PH, Park SJ, Seo Y, Namkung W, Kim SH, Kiem PV Tags: Nat Prod Res Source Type: research