Effects of ABO Incompatibility on the outcome of Allogeneic Hematopoietic Stem Cell Transplantation
This study aimed to investigate the outcome of AHSCT patients focusing on compatibility statues.
Conclusions: Salvage chemotherapy (often with rituximab and radiotherapy), followed by HDT and stem cell transplantation, appears to be the standard real-world treatment for rrPMBCL. However, large prospective and retrospective studies are warranted to improve our knowledge of real-world treatment patterns. PMID: 31951774 [PubMed - as supplied by publisher]
This study adds to the body of evidence in describing incidence and type of cardiac events experienced by an allogeneic and autologous HSCT population at one institution from 2012-2017. Sixty-five patients (9.8%) experienced cardiac events, including atrial arrhythmia (N = 39), acute heart failure (N = 9), acute coronary syndrome (N = 7), new onset hypertension (N = 9), with a few instances of bradycardia, ventricular arrhythmia, pericardial effusion, and pericarditis. Our multivariable regression analysis identified age (older), creatinine (higher) and history of coronary artery disease to significantly correlate with ris...
More than 2 billion people are infected with hepatitis B virus (HBV) worldwide. The prevalence of chronic HBV infection is high (6.2%) in the Western Pacific and African regions . Many researchers are aware of the risk of HBV reactivation in previously infected patients during immunosuppressive therapies such as chemotherapy, rituximab therapy and glucocorticoids [2,3]. The prevalence of hepatitis B core antibody (HBcAb) ranges from 5% in Western countries to>50% in Far Eastern countries [4 –6].
Purpose of review Optic neuropathies refer to a collection of diseases in which retinal ganglion cells (RGCs), the specialized neuron of the retina whose axons make up the optic nerve, are selectively damaged. Blindness secondary to optic neuropathies is irreversible as RGCs do not have the capacity for self-renewal and have a limited capacity for self-repair. Numerous strategies are being developed to either prevent further RGC degeneration or replace the cells that have degenerated. In this review, we aim to discuss known limitations to regeneration in central nervous system (CNS), followed by a discussion of previous,...
Bone Marrow Transplantation, Published online: 17 January 2020; doi:10.1038/s41409-020-0783-yBendamustine-EAM versus BEAM regimen in patients with mantle cell lymphoma undergoing autologous stem cell transplantation in the frontline setting: a multicenter retrospective study from Lymphoma Study Association (LYSA) centers
In conclusion, implantation of steroidogenic cells derived from ADSCs into bAdx mice increased the basal plasma corticosterone level and extended the survival of bAdx mice, suggesting the capability of restoring steroidogenic cells by cell transplantation therapy for adrenal insufficiency. PMID: 31950150 [PubMed - as supplied by publisher]
This study describes the incidence and type of cardiac events (CE) experienced by autologous and allogeneic hematopoietic stem cell transplant patients over a five-year period at one institution. 9.8% of patients experienced a CE, and those that experienced a CE had an increased risk of death within one year (p
We report one case of a recent renal transplant recipient, who presented with gastrointestinal and respiratory symptoms, evolving into shock. The identification of Strongyloides stercoralis in the bronchoalveolar lavage (BAL) lead us to the diagnosis of SHS. Treatment with subcutaneous ivermectin was started, however the patient did not survive. Retrospective serum donor analysis allowed us to identify the donor as the source of infection.
Conditions: Acute Myeloid Leukemia in Remission; Acute Lymphoblastic Leukemia in Remission; Myelodysplastic Syndromes Intervention: Drug: Allogeneic Stem Cell Transplantation Sponsors: Universitätsklinikum Hamburg-Eppendorf; DKMS Stiftung Leben Spenden; Clinical Trial Center North (CTC North GmbH&Co. KG) Recruiting
Authors: Li S, Bi Y, Wang Q, Xu M, Ma Z, Yang Y, Chang Y, Chen S, Liu D, Duan Z, Hong F, Chen Y Abstract Acute liver failure (ALF) is a disease with a considerably high mortality rate that still lacks a safe and effective treatment. Transplantation of liver stem cells (LSCs) has been considered to be a promising therapeutic alternative for ALF since LSCs have been shown to be involved in immunomodulation and functional reconstruction of the liver. Our present study evaluated and compared the protective effects of the two mouse LSC lines, YE and R5, as well as those of adult mouse hepatocyte (HC), on concanavalin A ...