Selecting the dosage of ceftazidime –avibactam in the perfect storm of nosocomial pneumonia
ConclusionsThis work serves as a successful practical example of dosage design for a new antibacterial drug therapy in the indication of NP, including VAP, where previous drug therapies have failed, possibly as a result of evaluation of too few variables, thereby limiting the accuracy of pharmacodynamic predictions.
Publication date: Available online 21 January 2020Source: The American Journal of SurgeryAuthor(s): Andrea Gillis, Ashley Pfaff, Ashar Ata, Alexa Giammarino, Steven Stain, Marcel TafenAbstractBackgroundIt is unclear what drives variation in timing to tracheostomy among different patients.MethodsAge, ethnicity, admission service, and income were retrospectively collected for patients undergoing tracheostomy in a level 1 trauma center from 2007 to 2017. The primary outcome was time to tracheostomy with early tracheostomy (ET) or late tracheotomy (LT) defined as 3–7 or ≥ 10 days post-intubation, respectively. Sec...
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Cases of a novel pneumonia-like illness that originated in Wuhan, China in December have now been confirmed in South Korea, Thailand, Japan, Taiwan, Macau—and, as of Jan. 21, the U.S. The virus’ geographic reach, as well as its newly discovered ability to spread via person-to-person contact, has health officials worried about the prospect of globals spread. As health officials scramble to learn more about the virus and is origins, researchers are simultaneously turning to the question of how to develop a vaccine or therapy that could help contain transmission worldwide—a feat that experts say is technical...
China’s government does not have a good record of openness with health scandals.
(Wiley) Emerging viral infections -- from bird flu to Ebola to Zika infections -- pose major threats to global public health, and understanding their origins can help investigators design defensive strategies against future outbreaks. A new study published in the Journal of Medical Virology provides important insights on the potential origins of the most recent outbreak of viral pneumonia in China, which started in the middle of December and now is spreading to Hong Kong, Singapore, Thailand, and Japan.
[IPS] Abuja -The coronavirus outbreak -- which began in Wuhan, China, and causes a pneumonia-like illness -- is raging across Asia, infecting close to 300 people and killing four. It was initially known to be transmitted from animals to human, and was just confirmed to be transmitted from human to human.
Macau confirmed on Wednesday its first case of pneumonia linked to an outbreak of a new coronavirus strain in the central mainland China city of Wuhan, China's state news agency Xinhua said.
ConclusionsLSW could significantly not only inhibit virus replication and proliferation in vitro, but also ameliorate pneumonia damage in vivo. The antiviral effect was attributed to down-regulating the expression of inflammatory cytokines induced by influenza virus via regulating the activity of TLR4/NF-кB signaling pathway.Graphical abstract
This article reviews the spectrum of activity, the main pharmacokinetic and pharmacodynamic characteristics of lefamulin as well as its clinical efficacy and safety in the treatment of CAP in adult patients.Expert opinion: The clinical efficacy of lefamulin in patients with non severe CAP has been demonstrated in 2 randomized clinical trials. Precisely one of the limitations of the phase 3 trials is that the proportion of severe CAP cases is very low. Its particular mechanism of action, affecting ribosomal protein synthesis, provides a low probability of cross-resistance to other commonly used antibiotics in CAP. These fin...
The male patient in Washington state was hospitalized with pneumonia last week and had recently traveled to Wuhan, a city of 11 million people in China where the outbreak is thought to have begun.