Overexpression of SMYD3 in Ovarian Cancer is Associated with Ovarian Cancer Proliferation and Apoptosis via Methylating H3K4 and H4K20

Conclusion: Our results demonstrated that SMYD3 was overexpressed in ovarian cancer and contributes to the regulation of tumor proliferation and apoptosis via SMYD3-H4K20me3-CDKN2A pathway and SMYD3-H3K4me3-BIRC3 pathway. Thus, SMYD3 is a promising epigenetic therapeutic target for ovarian cancer.

Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yahui Jiang, Tianjiao Lyu, Xiaoxia Che, Nan Jia, Qin Li, Weiwei Feng Tags: Research Paper Source Type: research