Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin α V β 3 and Mediating α V β 3/Src/E2F1 Signaling
Conclusion: These findings indicate that Fucoidan-Sargassum has an antimetastatic effect on SMMC-7721, Huh7 and HCCLM3 liver cancer cells, and the underlying mechanism involves targeting ITGαVβ3 and mediating the ITGαVβ3/SRC/E2F1 signaling pathway. These results suggest that Fucoidan-Sargassum may be a promising therapeutic antimetastatic compound in the development of a metastasis-preventive drug for treating liver cancer.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Ting-Jia Pan, Li-Xin Li, Jia-Wei Zhang, Zhao-Shuo Yang, Dong-Min Shi, Yun-Ke Yang, Wei-Zhong Wu Tags: Research Paper Source Type: research
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