Downregulated Salt-inducible Kinase 3 Expression Promotes Chemoresistance in Serous Ovarian Cancer via the ATP ‐ binding Cassette Protein ABCG2

Conclusion: Our results demonstrated that serous EOC patients with low SIK3 expression have poor prognosis, which is associated with chemoresistance mediated by ABCG2 upregulation. SIK3 and ABCG2 expression levels may be potential prognostic markers to predict the outcome in serous EOC patients.

Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yu-Ling Liang, Chin-Han Wu, Chieh-Yi Kang, Chang-Ni Lin, Neng-Yao Shih, Sheng-Hsiang Lin, Yeong-Chang Chen, Keng-Fu Hsu Tags: Research Paper Source Type: research