Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin

Conclusions: SLFN11 is frequently methylated in human gastric cancer, and its expression is regulated by promoter region methylation. Our results demonstrate that SLFN11 is a tumor suppressor in human gastric cancer, and methylation of SLFN11 may serve as a cisplatin resistant marker in human gastric cancer.

Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yaojun Peng, Li Wang, Liangliang Wu, Ling Zhang, Guangjun Nie, Mingzhou Guo Tags: Research Paper Source Type: research