Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer

In this study, we report a novel lncRNA, LINC00467, which was significantly up-regulated in CRC; we investigated its function and mechanism in CRC. Our study demonstrated that LINC00467 levels in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. We used the Gene Expression Omnibus (GEO) and Gene Expression Profiling Interactive Analysis (GEPIA) databases for the analysis and measurement of clinical samples, and observed that the CRC patients with high LINC00467 expression levels showed poor overall survival (OS) and recurrent-free survival (RFS) rates. Furthermore, following the short interfering RNA (siRNA) knockdown of LINC00467 in the CRC cell line, the results demonstrated that LINC00467 suppresses the proliferation, invasion and metastasis of CRC cells in vitro. Moreover, its molecular mechanism of LINC00467 decreased the expression of Cyclin D1, Cyclin A1, CDK2, CDK4 and Twist1 as well as enhanced the expression of E‑cadherin. Collectively, these findings suggest that LINC00467 may be crucial in the progression and development of CRC, and may serve as a potential therapeutic target for CRC patients.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

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Patients with inflammatory bowel disease demonstrate selenium nutritional deficiencies and are at increased risk  for colon cancer. Previously, we determined that global loss of the selenium-containing antioxidant protein, Selenoprotein P (SELENOP), exacerbates experimental colitis-associated cancer (CAC). Using a variety of tissue-specific knockout mouse lines, we further determined that epithelial-derived SELENOP served as the primary mediator of disease severity, and Villin-Cre; Selenop f/f (Selenop ΔIEC) mice have increased tumor incidence, number, size, and dysplasia as compared to WT cohorts.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
The objective of this study is to assess gastroenterologists ’ current attitudes and barriers toward chromoendoscopy in IBD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research
This study analyzes the impact of tumor deposits (TDs), T and N status, poor differentiation (PD), perineural invasion (PNI), and lymphovascular invasion (LVI) on survival. Materials and Methods: A retrospective analysis (2010-2015) of the National Cancer Database of stage III colon cancer patients treated with both surgery and chemotherapy was conducted. Data was extracted on sex, race, age at diagnosis, Charlson-Deyo Score, histopathologic variables, and survival rates. Statistical analysis used the test of proportions, log-rank test for Kaplan-Meier curves, and Cox proportional hazard models. Results: For the 42,9...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
BOWEL cancer is any cancer that affects the colon and rectum. Bowel cancer is the fourth most common cancer in the UK and the second biggest cancer killer. Knowing the early signs of the deadly disease is crucial and should not be ignored. What are the five signs to look out for when a person goes to the toilet?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
By HANS DUVEFELT, MD I’ve had several telephone calls in the last two weeks from a 40-year-old woman with abdominal pain and changed bowel habits. She obviously needs a colonoscopy, which is what I told her when I saw her. If she needed an MRI to rule out a brain tumor I think she would accept that there would be co-pays or deductibles, because the seriousness of our concern for her symptoms would make her want the testing. But because in the inscrutable wisdom of the Obama Affordable Care Act, it was decided that screening colonoscopies done on people with no symptoms whatsoever are a freebie, whereas colon...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Primary Care Colonoscopy Hans Duvefelt Health insurance Source Type: blogs
Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1. Oncol Lett. 2020 Feb;19(2):1131-1136 Authors: Zhou T, Wu L, Zong Z, Ma N, Li Y, Jiang Z, Wang Q, Chen S Abstract Long non-coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer in humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation of lncRNA MORT in the tumor tissues of patients with colon cancer. The expression of MORT in tumor tissues was linearly associated ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: 15 April 2020Source: Journal of Molecular Structure, Volume 1206Author(s): Kazem Karami, Nasrin Jamshidian, Atefe Bagheri, Afsaneh Hajiaghasi, Amir Abbas Momtazi-Borojeni, Elham Abdollahi, Azar Shahpiri, Negar Azizi, Janusz LipkowskiAbstractThe new alkoxime ligand (E)-anthracene-9-carbaldehyde-O-methyl oxime (1) derivative of 9-anthraldehyde and its palladium (II) complexes trans-Pd(C15H10NOCH3)2(OAc)2 (2) and [cis-Pd(C15H10NOCH3)(Py)2(OAc)](OAc) (3) were synthesized and characterized by spectroscopic techniques. Also, the ligand (1) structure was characterized by X-ray crystallography. Then their interac...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 22 January 2020Source: PeptidesAuthor(s): Anshul Panjeta, Simran PreetAbstractThe escalating predicament of multidrug resistant cancer cells and associated side effects of conventional chemotherapy necessitates the exploration of alternative anticancer therapies. The present study evaluated anticancer therapeutic potential of human defensin 5 (HD-5) against colon cancer. The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morp...
Source: Peptides - Category: Biochemistry Source Type: research
In conclusion, DAC uptake mainly via ENT1 may be described by a bidirectional first-order kinetic parameter, while phosphorylation by dCK may be described by Michaelis-Menten parameters. PMID: 31964620 [PubMed - as supplied by publisher]
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
ConclusionModified Y-shaper pouch is suitable for short, dilated ureters. Longitudinal orientation of the pouch facilitates ileo-urethral anastomosis, especially with short mesentery. Long-term follow-up for direct uretero-ileal anastomosis did not show deterioration of the renal function.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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