Significant prognostic values of differentially expressed-aberrantly methylated hub genes in breast cancer

Conclusion: Overexpression of TOP2A, MAD2L1, FEN1, EPRS, EXO1, MCM4, PTTG1, RRM2, PSMD14, CDKN3, H2AFZ, CCNE2 and downregulation of FGF2, BCL2, PIK3R1 might serve as diagnosis and poor prognosis biomarkers in breast cancer by more research validation. EXO1 was identified as an individual unfavorable prognostic factor. Methylation might be one of the major causes leading to abnormal expression of those genes. Functional analysis and pathway enrichment analysis of those genes would provide novel ideas for breast cancer research.

Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lina Qi, Biting Zhou, Jiani Chen, Wangxiong Hu, Rui Bai, Chenyang Ye, Xingyue Weng, Shu Zheng Tags: Research Paper Source Type: research