A Systematic Inflammation-based Model in Advanced Pancreatic Ductal Adenocarcinoma

In conclusion, the nomogram based on inflammatory biomarkers can serve as useful prognostic tool for advanced PDAC. In addition, patients with high NTP can greater benefit from combination chemotherapy than monotherapy.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

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Conclusions: These findings uncover a novel effect and mechanism of action of the antiplatelet drug ticagrelor in PDAC cells and suggest a multi-functional role for ADP-P2Y12 signalling in the tumour microenvironment.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Xie L, Xia L, Klaiber U, Sachsenmaier M, Hinz U, Bergmann F, Strobel O, Büchler MW, Neoptolemos JP, Fortunato F, Hackert T Abstract Background: The progression and response to systemic treatment of cancer is substantially dependent on the balance between cancer cell death (apoptosis and necroptosis) and cancer cell survival (autophagy). Although well characterized in experimental systems, the status of cancer cell survival and cell death in human pancreatic ductal adenocarcinoma (PDAC), especially in response to chemotherapy and different types of chemotherapy is poorly described. Results: The median ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 6 January 2020Source: Journal of Geriatric OncologyAuthor(s): Rishi Jain, Namrata Vijayvergia, Karthik Devarajan, Bianca Lewis, Crystal S. Denlinger, Steven J. Cohen, Efrat DotanAbstractBackgroundWhile a number of landmark clinical trials have led to the approval of combination chemotherapy regimens for metastatic pancreatic adenocarcinoma (mPC), older patients are underrepresented in these studies. We evaluated changes in practice patterns in the management of mPC among medical oncologists in the combination chemotherapy era (CCE).MethodsA retrospective analysis of patients treated at a ...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Stage IA Pancreatic Adenocarcinoma;   Stage IB Pancreatic Adenocarcinoma;   Stage IIA Pancreatic Adenocarcinoma;   Stage IIB Pancreatic Adenocarcinoma Interventions:   Drug: nab-paclitaxel;   Drug: Gemcitabine;   Drug: tegafur Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractBackgroundPrognostic prediction had been widely used in various cancer entities, from early screening to end-stage patient caring. Currently, there is hardly any well-validated nomogram which exists for long-term survival prediction in pancreatic adenocarcinoma (PC) patients in a post-surgery setting. Our objectives are to identify possible prognostic factors in PC patients following radical resection and to develop a prognostic nomogram based on independent survival predictors.MethodsFrom 2009 to 2014, a total of 432 PC patients who underwent curative intended surgeries with complete follow-up data were included i...
Source: World Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 26 December 2019Source: Journal of Geriatric OncologyAuthor(s): Richard Li, Jessica Vazquez, Jennifer Novak, Mina Sedrak, Susanne Warner, Scott Glaser, Yi-Jen Chen, William Dale, Arya AminiAbstractIntroductionOlder adults are underrepresented in landmark trials that determine treatment guidelines for pancreatic cancer. We used the National Cancer Database (NCDB) to compare treatment patterns and outcomes in stage I-III pancreatic cancer between older adult patients, defined as age 80 or older, to patients younger than 80.Material and MethodsWe identified 140,678 patients in the NCDB diagn...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Background: The C-reactive protein (CRP)-to-serum albumin ratio is associated with a poor prognosis in patients with several cancers. The purpose of this study was to clarify the relationship between the preoperative CRP/Alb ratio and overall survival of pancreatic ductal adenocarcinoma (PDAC) in patients who received radical surgery and S-1 adjuvant chemotherapy. Patients and Methods: We included 117 patients who underwent radical surgery with S-1 adjuvant chemotherapy. We constructed receiver operating characteristic curve (ROC curve) of the CRP/Alb ratio to determine the cut-off value. We analyzed the relationship among...
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
To the Editor We read with interest the study of Hank et al, which proposes that there is a decreased risk of developing clinically relevant pancreatic fistula (CR-POPF) when neoadjuvant chemotherapy (NAT) therapy is applied for pancreatic adenocarcinoma. They suggest induction of fibrosis of the pancreatic gland as a proposed mechanism. While the data appear intriguing, there are some methodologic issues that raise questions.
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
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