The Prognostic Significance of Pure Ground Glass Opacities in Lung Cancer Computed Tomographic Images

Conclusions: As a subgroup of GGO nodules, pure GGO nodules predict a better prognosis in all lung cancer patients. Wheras our study showed that lung patients with pure GGO nodules in similar stages were not significantly different in long-term prognoses, in the short term; patients with pure GGO nodules had longer PFS.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

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ConclusionsThe PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusion Lung adenocarcinoma with miliary metastasis in both lungs is a rare phenomenon. We should pay attention to the performance to avoid misdiagnosis. Most of the adenocarcinoma subtypes have EGFR mutations, and EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are the preferred treatment choice for this type of patients. DOI: 10.3779/j.issn.1009-3419.2019.12.11
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion: Some cases of ICC may be responsive to the antiangiogenic drug, anlotinib, when combined with microwave ablation. Randomized clinical studies are required to further confirm the efficacy and safety of anlotinib in the clinical treatment of ICC.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
There are limited data on the clinical efficiency of afatinib in non ‐small cell lung cancer (NSCLC) patients with uncommon epidermal growth factor receptor (EGFR) mutations. Moreover, the efficacy and safety of afatinib in elderly patients with these mutations has not been established. Here, we describe a case of successful treatment of a patient aged>80  years with lung adenocarcinoma positive for the uncommon EGFR L861Q mutation with low‐dose afatinib. An 83‐year‐old woman presented with cough and dyspnea. A chest computed tomography (CT) scan revealed tumors in the left upper lobe, left pleural effusi...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
Traditionally, “high-risk” populations for lung cancer refer to male smokers age 55 to 74 years who have had a malignancy or whose parent(s) had lung cancer. However, due to the widespread application of low-dose computed tomography (LDCT) scanning in China, many young female nonsmokers and those without a hi story of malignancy or family history have been diagnosed with early-stage lung adenocarcinoma. The nodules manifest as ground-glass nodules (GGNs), which are adenocarcinoma in situ, minimally invasive adenocarcinoma, or lepidic predominant adenocarcinoma pathologically.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
Non-calcified nodules (NCNs) associated with false positive low-dose CT (LDCT) screens for lung cancer have been attributed to various causes, including infectious and inflammatory processes [1,2]. There is also evidence that some NCNs may represent lung cancer precursors. This evidence comes from case series of surgically resected NCNs, where some lesions have been shown to represent atypical adenomatous hyperplasia, a lung adenocarcinoma precursor [3,4]. Further indirect support for this hypothesis comes from a study of participants in the National Lung Screening Trial (NLST) who had NCNs found on LDCT screening [5].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: A COPD/emphysema based strategy for the selection of LCS candidates is feasible. The prevalence of LC in our high risk cohort was 2.31%. 64% of patients were operable, and median survival at 4 years was 94%.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Introduction: Bronchiectasis has been classified as a comorbidity of COPD patients, associated with frequent exacerbations and severity of airflow limitation. In our study, we investigated the prevalence and characteristics of bronchiectasis in the lung cancer screening (LCS) program.Material and methods: A transversal study was performed. From 2014 until September 2018, 1005 patients were included in our LSC program. Of these, 949 had low-dose computed tomography (LDCT). The subjects met the NLST criteria (age between 55 and 75 who have a 30 pack-year smoking history and are currently smoking or have quit within the past ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Conclusions: This retrospective analysis showed that pre-bronchoscopy gargling with water may contribute to the reduction of bronchoscopy-related infection.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Conclusions: The main clinicopathological type of lung cancer in young lung cancer patients aged 30 years and younger is adenocarcinoma, and most cases were at the early stage. Surgical treatment based on lobectomy is still the main treatment method and the prognosis of these patients is very good. Early screening of lung cancer should be actively promoted for young people. PMID: 31737313 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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