Evaluation of protective efficacy of inactivated Mycoplasma synoviae vaccine with different adjuvants

Publication date: Available online 12 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Xiaowei Gong, Qiwei Chen, Naola Ferguson-Noel, Laszlo Stipkovits, Susan Szathmary, Yongsheng Liu, Fuying ZhengAbstractMycoplasma synoviae (MS) is a poultry pathogen with a reported distribution throughout the world. Vaccination is utilized as an important component of MS control programs for MS infection. The aim of this study was to evaluate protection efficacy of an inactivated MS vaccine (MS bacterin) with different adjuvants in broilers against a Chinese field isolate (CHN-BZJ2-2015). Vaccination with adjuvants ISA 71 V G and chitosan, respectively, enhanced specific lymphocyte proliferation responses and upregulated the expression of IL-1β, IL-6, IL-2 and IFN-γ prior to challenge. Furthermore, vaccination with adjuvant ISA 71 V G elicited the highest antibody titers, exhibited significantly lower air sac, foot pad and tracheal lesions than the other groups (P < 0.05), and decreased MS colonization. These results demonstrated that inactivated MS vaccine with ISA 71 VG is able to induce both cellular and humoral immune response in broilers and confers a high level of protection upon challenge, demonstrating a potential application in the field.
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research