Evaluation of protective efficacy of inactivated Mycoplasma synoviae vaccine with different adjuvants

Publication date: Available online 12 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Xiaowei Gong, Qiwei Chen, Naola Ferguson-Noel, Laszlo Stipkovits, Susan Szathmary, Yongsheng Liu, Fuying ZhengAbstractMycoplasma synoviae (MS) is a poultry pathogen with a reported distribution throughout the world. Vaccination is utilized as an important component of MS control programs for MS infection. The aim of this study was to evaluate protection efficacy of an inactivated MS vaccine (MS bacterin) with different adjuvants in broilers against a Chinese field isolate (CHN-BZJ2-2015). Vaccination with adjuvants ISA 71 V G and chitosan, respectively, enhanced specific lymphocyte proliferation responses and upregulated the expression of IL-1β, IL-6, IL-2 and IFN-γ prior to challenge. Furthermore, vaccination with adjuvant ISA 71 V G elicited the highest antibody titers, exhibited significantly lower air sac, foot pad and tracheal lesions than the other groups (P 
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research

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Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Date: Friday, 01 24, 2020; Speaker: Diane L. Bolton, Ph.D., Chief, Animal Models&Pathogenesis Section, US Military HIV Research Program; 33; 1N09
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: March 2020Source: Veterinary Microbiology, Volume 242Author(s): Chuangang Liu, Jianglong Li, Qili Yao, Zhisong Gao, Yanqing Cheng, Meiling Zhou, Yajie Tang, Leqiang Sun, Jinxia Dai, Gang Cao, Xiao-Lian Zhang, Ran ZhangAbstractRabies is a highly lethal infectious zoonosis caused by rabies virus (RABV), and the mortality rate is almost 100 % once clinical symptoms appear, which poses a huge threat to public health security across the many parts of the word. Vaccination is reported to be the most effective approach to prevent the disease. G protein is the only protein present on the surface of RABV, it also ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 January 2020Source: Veterinary MicrobiologyAuthor(s): Yongzhen Liu, Zengkun Xu, Yu Zhang, Mengmeng Yu, Suyan Wang, Yulong Gao, Changjun Liu, Yanping Zhang, Li Gao, Xiaole Qi, Hongyu Cui, Qing Pan, Kai Li, Xiaomei WangAbstractThe CRISPR/CRISPR-associated protein 9 (Cas9) system is a powerful gene-editing tool originally discovered as an integral mediator of bacterial adaptive immunity. Recently, this technology has been explored for its potential utility in providing new and unique treatments for viral infection. Marek’s disease virus (MDV) and avian leukosis virus subgroup J (ALV...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 16 January 2020Source: Veterinary MicrobiologyAuthor(s): Yan-Wu Wei, Hong-Zhen Zhu, Li-Ping Huang, De-Li Xia, Hong-Li Wu, Hai-Qiao Bian, Li Feng, Chang-Ming LiuAbstractCoinfection with porcine circovirus type 2 (PCV2) and Mycoplasma hyorhinis (Mhr) can induce more-severe disease than a single infection with either. We evaluated the efficacy of a new vaccine combining inactivated PCV2 and Mhr, in a model of PCV2 and Mhr infection. Twenty-five 35-day-old PCV2- and Mhr-free pigs were randomly divided into five groups, with five pigs in each group. The pigs in groups 1 and 2 were vaccinated w...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Flu season is always unpredictable. Different viral strains circulate each year, which makes forecasting the disease’s spread—and formulating the annual flu vaccine—an educated guessing game. Even so, the 2019-2020 flu season has been particularly unusual. Influenza B, the viral strain that usually circulates toward the end of flu season, instead emerged first this year, shifting usual transmission patterns. A vaccine mismatch and reduced immunity to influenza B may have contributed to the early and severe start of this flu season. What does that mean for the months ahead? TIME asked Lynnette Brammer, an ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease Source Type: news
Publication date: Available online 12 January 2020Source: Microbial PathogenesisAuthor(s): Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. UverskyAbstractThe Nipah Virus (NiV) was first isolated during a 1998–9 outbreak in Malaysia. The outbreak initially infected farm pigs and then moved to humans from pigs with a case-fatality rate (CFR) of about 40%. After 2001, regular outbreaks occurred with higher CFRs (∼71%, 2001–5, ∼93%, 2008–12). The spread arose from drinking virus-laden palm date sap and human-to-human transmission. Intrinsic disorder analysis revealed strong correla...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 11 January 2020Source: Microbial PathogenesisAuthor(s): An-Qi Ju, Shu-bao Yang, Hai-Peng Zhang, Xin Ma, Dong-Xing Zhang, Yuan-huan Kang, Shi-qiu Mei, Tong-lei Wu, Gui-Qin Wang, Ai-Dong Qian, Xiao-feng Shan, Wei-Min LuanAbstractAeromonas veronii is an important zoonotic pathogen that causes significant economic losses in the aquaculture industry. The use of probiotics in aquaculture is a practical alternative to antibiotics to promote animal health and aid in disease prevention. In the present study, we aimed to construct a recombinant Lactobacillus casei(surface-displayed or secretory) st...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
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