Polydatin Inhibits Adipose Tissue Inflammation and Ameliorates Lipid Metabolism in High-Fat-Fed Mice.

In conclusion, PD may serve as a pharmaceutic candidate for obesity-related lipid metabolism, anti-inflammation, and body weight loss. PMID: 31828124 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined 42 healthy female physique athletes (age 27.5 ± 4.0 years, body mass index 23.4 ± 1.7 kg/m2) volunteered into either a diet group (n = 25) or a control group (n = 17). For the diet group, the energy intake was reduced and exercise levels were increased to induce loss of fat mass that was subsequently regained during a recovery period. The control group was instructed to maintain their typical lifestyle, exercise levels, and energy intake at a constant level. For quantification of systems biology markers, fasting blood samples were drawn at three time points: baseline (PRE), at the end of the weigh...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Mildren Porchas-Quijada1, Zyanya Reyes-Castillo1*, José Francisco Muñoz-Valle2, Sergio Durán-Barragán3,4, Virginia Aguilera-Cervantes1, Antonio López-Espinoza1, Mónica Vázquez-Del Mercado4, Mónica Navarro-Meza1 and Patricia López-Uriarte1 1Instituto de Investigaciones en Comportamiento Alimentario y Nutrición, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Mexico 2Instituto de Investigaciones en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexic...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Alexandra Neyazi1†, Vanessa Buchholz1†, Alexandra Burkert1, Thomas Hillemacher1,2, Martina de Zwaan3, Wolfgang Herzog4, Kirsten Jahn1, Katrin Giel5, Stephan Herpertz6, Christian A. Buchholz1, Andreas Dinkel7, Markus Burgmer8, Almut Zeeck9, Stefan Bleich1, Stephan Zipfel5† and Helge Frieling1*† 1Molecular Neuroscience Laboratory, Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School (MHH), Hannover, Germany 2Department of Psychiatry and Psychotherapy, Paracelsus Medizinische Privatuniversität Nürnberg, Nuremberg, Germany 3Department of Psychos...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion Preclinical and clinical studies have demonstrated that treatment with antipsychotics and metformin had effects on the gut microbiota and the brain. Although the mechanism of the effects of metformin on AIMD remains unclear, there are some clues in the regulation of the gut-brain axis (Figure 1). The most important connections between metformin and AIMD in the gut microbiota were the mucin-degrading bacteria A. muciniphila and several SCFA-producing bacteria, such as the phyla Firmicutes and Bacteroidetes. The gut microbiota were was influenced during AIMD, and these changes included a decrease in A. muciniphil...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Our study demonstrated that serum IL-15 concentrations in adolescent girls with anorexia nervosa and obesity are significantly elevated in comparison to normal weight controls. However, the role of IL-15 in the pathogenesis of anorexia nervosa and obesity remains still unclear. PMID: 30806157 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
There’s a ton of incredibly promising intermittent fasting (IF) research done on fat rats. They lose weight, their blood pressure, cholesterol, and blood sugars improve… but they’re rats. Studies in humans, almost across the board, have shown that IF is safe and incredibly effective, but really no more effective than any other diet. In addition, many people find it difficult to fast. But a growing body of research suggests that the timing of the fast is key, and can make IF a more realistic, sustainable, and effective approach for weight loss, as well as for diabetes prevention. The backstory on intermit...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Health Source Type: blogs
Here’s how to take that first small step. Food addiction is real. And if you’re struggling with food addiction, know that you’re not alone — I’ve been there, too. In fact, the younger you are, the more likely it’s your struggle. From my past experience as a compulsive overeater, I suspect that many food addictions act as pacifiers for pain, fears, and anxieties, and even as ways to celebrate emotional spikes that are positive. Food seems to act as a life enhancer, while offering the illusion of short-term emotional balance. As a food addict, you’ve established neural pathways and a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Addiction Eating Disorders Exercise & Fitness Health-related Personal Publishers YourTango Binge Eating Compulsion Food Addiction Healthy Eating obese overeating Overweight Weight Gain Source Type: blogs
Publication date: Available online 8 January 2018 Source:Chemico-Biological Interactions Author(s): Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Dhreerendra Pandey, Hiren Patel, Ramchandra Ranvir, Shekhar Kadam, Dipam Patel, Rajesh Bahekar, Mukul Jain Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Abstract Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and glucagon receptors in complications of diet-induced dyslipidemia in hamsters and humanized double transgenic mice. Hamsters fed on high fat high cholesterol diet were treated for 8 weeks with coagonist of GLP-1 and glucagon receptors (75 and 150 μg/kg). Pair-fed control...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
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