Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor

Angiotensin-(1-7) [Ang-(1-7)], a component of the renin angiotensin system, is a vasodilator that exerts its effects primarily through the Mas receptor. The discovery of the Mas receptor in white adipose tissue (WAT) suggests an additional role for this peptide. The aim of the present study was to assess whether Ang-(1-7) can induce the expression of thermogenic genes in white adipose tissue and increase mitochondrial respiration in adipocytes.

Source: Metabolism - Clinical and Experimental - December 12, 2019 Category: Biomedical Science Authors: Ariana Vargas-Castillo, Sandra Tobon-Cornejo, Leonardo Del Valle-Mondragon, Ivan Torre-Villalvazo, Alejandro Schcolnik-Cabrera, Martha Guevara-Cruz, Edgar Pichardo-Ontiveros, Rebeca Fuentes-Romero, Michael Bader, Natalia Alenina, Antonio Vidal-Puig, Enriq Source Type: research