Construction of an efficient nonleaching graphene nanocomposites with enhanced contact antibacterial performance

Publication date: 15 February 2020Source: Chemical Engineering Journal, Volume 382Author(s): Lei Jiang, Yanyi Wen, Zhongjie Zhu, Chen Su, Shan Ye, Jie Wang, Xiufeng Liu, Wei ShaoAbstractContact antibacterial amoxicillin grafted GO (Am-g-GO) nanocomposites with nonleaching activity were prepared. Transmission electron microscopy, Atomic force microscopy, Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy were applied to analyze the structure and chemical composition of Am-g-GO nanocomposites. In order to study the relationship between antibacterial property and the dosage of Am-g-GO nanocomposites, the antibacterial growth behaviors of Am-g-GO nanocomposites with different concentrations were carried out against E. coli and S. aureus. The possible antibacterial mechanism was also investigated using XTT assay and Ellman’s assay to determine any ROS production. More importantly, the Am-g-GO nanocomposites display good biocompatibility. These results indicate that Am-g-GO nanocomposites could be an efficient antibacterial agents without any leaching, possessing great potentials in many antibacterial fields.Graphic abstract
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research

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This study suggests that intestinal inflammation and reduction of short chain fatty acids (SCFAs) caused by the imbalance of gut microbiota are crucial to the pathogenesis of T1DM.Graphical abstractIn this study, LEfSe multilevel species hierarchical tree directly reflects the differences of gut microbiota between control and T1DM rats at the Phylum-to-Family level, the result showed that the gut microbiome of T1DM rats changed significantly. The abundance of pathogenic bacteria associated with infection and inflammation in T1DM rats was up-regulated such as Ruminococcaceae, Shigella, Enterococcus, Streptococcus, Rothia an...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, this real-time PCR should advance further studies on these parasites and may inspire research on related species, not only in the Americas, but also in other parts of the world.Graphical abstract
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Authors: Mori T, Nagao-Sato S, Kishino K, Namba T, Hara-Kudo Y Abstract Alkali-heat DNA extraction, a rapid and economical method, was evaluated for use in the detection of Shiga toxin-producing Escherichia coli in food using real-time PCR assays. Alkali-heat DNA extracts led to highly sensitive detection (102-104 CFU/mL) of stx and O-antigen genes in beef liver, ground beef, sliced pork, cheese, lettuce, radish sprouts, tomato, and spinach, equivalent to the sensitivity obtained using a commercial DNA extraction kit that utilizes proteinase K lysis, and silica membrane purification. Although there were differences...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - Category: Food Science Tags: Shokuhin Eiseigaku Zasshi Source Type: research
CONCLUSIONS: This work has revealed that a modified live bacterial therapeutic, EcN-GM, has potential beneficial effects on obesity. This effect may be related to the regulating of the neuropeptide expression of energy intake and expenditure in the hypothalamus. This study demonstrates a successful example of engineered EcN-GM as a novel approach for weight management. PMID: 31970910 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Goblet cells, specialized epithelial cells that produce mucus, are essential for gut health. Dysfunctional goblet cell secretion can weaken the mucus barrier, bringing commensal microbes and other lumenal contents in contact with the epithelial barrier, triggering inflammation. We recently discovered that murine astroviruses infect goblet cells in the small intestine, making it the first enteric virus in which this tropism has been recognized in vivo. To first determine whether astrovirus infection alters mucus production in goblet cells, we used periodic acid-Schiff staining of small intestinal tissues and found a thicker...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
While the molecular mechanisms by which the microbiome modulates mucosal immunity in Crohn ’s disease (CD) are still largely unknown, recent data highlight the involvement of specific diet- and bacterial-derived metabolites in the regulation of intestinal immune cell activation and differentiation. We have recently shown that Adherent-Invasive E.coli (AIEC), which are enriched in CD pat ients, are sufficient to induce intestinal Th17 cells. Although AIEC lack pathogenic factors including type III secretion systems, many CD-derived isolates express virulence-associated metabolic enzymes including propanediol dehydrata...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Innate and Mucosal Immunology and Immunity Source Type: research
Publication date: Available online 23 January 2020Source: SteroidsAuthor(s): Gervais Mouthé Happi, Steven Collins N. Wouamba, Mohamed Ismail, Simeon Fogue Kouam, Marcel Frese, Bruno Ndjakou Lenta, Norbert SewaldAbstractTwo new ergostane-type steroids named tiamenones A and B (1–2) were isolated from the bark of Entandrophragma angolense (Meliaceae) along with ten known compounds identified as 20S-hydroxy-4,6,24(28)-ergostatrien-3-one (3), 3β,7α,20β-trihydroxyergosta-5,24(28)-diene (4), 3β,5α-dihydroxyergosta-7,22-diene (5), stigmasterol, β-sitosterol, β-amyrin, oleanolic ac...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
This study provides scientific data to better understand the risks of potential VBNC foodborne pathogens during fresh produce washing.
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 23 January 2020Source: Process BiochemistryAuthor(s): Prakashkumar Nallasamy, Thenmozhi Ramalingam, Nooruddin Thajuddin, Rajasree Shanmuganathan, Arivalagan Pugazhendhi, Suganthy NatarajanAbstractStarch is a natural, renewable biopolymer widely used in pharmaceutical industry for the controlled release of drugs and hormones. Triphala Churna (TC) a tridoshic rasayana, rich in polyphenols and vitamin C possess balancing and rejuvenating effect on three constitutional elements that govern the human life. To enhance the solubility and efficiency of the ayurvedic drug TC, attempts were made to...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
Publication date: Available online 23 January 2020Source: Pesticide Biochemistry and PhysiologyAuthor(s): Xiao-Qing Zhang, Qi Yan, Lu-Lu Li, Ji-Wei Xu, Dingze Mang, Xue-Liang Wang, Hong-Huat Hoh, Jia Ye, Qian Ju, Yu Ma, Meng Liang, Yun-Ying Zhang, Xiu-Yun Zhu, Fan Zhang, Shuang-Lin Dong, Ya-Nan Zhang, Long-Wa ZhangAbstractAthetis lepigone (Alep) is a polyphagous pest native to Europe and Asia that has experienced major outbreaks in the summer maize area of China since 2011 and has shown evidence of resistance to some insecticides. Insect olfaction is crucial for recognition of sex pheromones, host plant volatiles and even ...
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research
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