Modafinil for people with schizophrenia or related disorders.

CONCLUSIONS: Due to methodological issues, low sample size, and short duration of the clinical trials as well as high risk of bias for outcome reporting, most of the evidence available for this review is of very low or low quality. For results where quality is low or very low, we are uncertain or very uncertain if the effect estimates are true effects, limiting our conclusions. Specifically, we found that modafinil is no better or worse than placebo at preventing worsening of psychosis; however, we are uncertain about this result. We have more confidence that participants receiving modafinil are no more likely to leave a trial early than participants receiving placebo. However, we are very uncertain about the remaining equivocal results between modafinil and placebo for outcomes such as improvement in global state or cognitive function, incidence of adverse events, and changes in quality of life. More high-quality data are needed before firm conclusions regarding the effects of modafinil for people with schizophrenia or related disorders can be made. PMID: 31828767 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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Conclusions: The 20% of EDS were diagnosed as BIISS, circadian rhythm sleep disorder, or disordered life pattern in Japan, which indicated the importance to educate sleep hygiene.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
As a rare and disabling neurological sleep disorder that is often diagnosed during adolescence, narcolepsy type 1 (NT1) has been described as a relatively homogeneous clinical syndrome of hypothalamic deficiency in hypocretin-1 (orexin) producing neurons.1,2 As up to 98% of patients are human leukocyte antigen DQB1*06:02 positive, an autoimmune-mediated hypothesis has been supported.3 The core features include excessive daytime sleepiness (EDS), cataplexy, fragmented nocturnal sleep with vivid dreams, and hallucinations and sleep paralysis during sleep-wake transitions.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Clinical Letter Source Type: research
The patient was a 15 years old female. She was increased daytime sleeping for 3 years, abnormal mental behavior for 10 months, and was admitted to our hospital in August 2014.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Narcolepsy Source Type: research
We report a case of an adolescent male who presented with all four cardinal symptoms of narcolepsy and had been misdiagnosed with epilepsy, psychosis, and depression. We discuss various issues regarding narcolepsy in children and adolescents. Keywords: narcolepsy, adolescence, misdiagnosis Innov Clin Neurosci. 2017;14(9–10):20–23 Introduction Narcolepsy is an uncommon sleep cycle disorder characterized by the tetrad of chronic excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis.1 The cardinal symptom of paroxysmal sleep is seen in all patients, whereas other symptoms such as ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research
Conclusion: Suvorexant treatment resulted in overall improvement in the quality of sleep and the severity of anxiety and depression. This dual orexin antagonist may be related to autonomic functions and neuroendocrine systems, especially in the hypothalamus-pituitary-adrenal axis in psychiatric subjects. Introduction The hypothalamus plays a critical role in the integrated control of sleep/wakefulness, thermogenesis, and energy homeostasis, and the lateral hypothalamus area (LHA) in this region has been regarded as an important center for arousal and feeding.[1] The neuropeptide orexin A and orexin B (also known as hypocre...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Current Issue Depression Original Research Psychiatry Psychopharmacology Sleep Disorders Autonomic nervous insomnia neuroendocrine orexin antagonist suvorexant Source Type: research
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.  Sarah DiGiulio is The Huffington Post’s sleep reporter. You can contact her at sarah.digiulio@huffingtonpost.com.     function onPlayerReadyVidible(e){'undefined'!=typeof HPTrack&&HPTrack.Vid.Vidible_track(e)}!function(e,i){if(e.vdb_Player){if('object'==typeof commercial_video){var a='',o='m.fwsitesection='+commercial_video.site_and_category;if(a+=o,commercial_video['package']){var c='&m.fwkeyvalues=sponsorship%3D'+...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Sleep is essential to the maintenance of mental health. Sleep helps to regulate mood and process emotional information and experiences into memory. Insufficient sleep is associated with increased emotional reactivity and emotional disturbance. Research indicates that REM sleep may play an especially significant role in maintaining emotional well-being and psychological balance. Sleep problems occur substantially more frequently in people with psychiatric conditions than in the general population. Often, sleep and mental health disorders exist in bi-directional relationship to each other, with each condition influencing the...
Source: Psych Central - Category: Psychiatry Authors: Tags: Anxiety Attention Deficit Disorder Bipolar Depression Disorders General Panic Disorder Psychology PTSD Schizophrenia Sleep Adhd Attention Deficit Hyperactivity Disorder Bipolar Disorder Emotional Disturbance emotional reactiv Source Type: news
CONCLUSION: It is difficult to study the presence of SP and HH in patients with active or residual symptoms of schizophrenia, and more refined studies and appropriate questionnaires are required. The possibility of SP and HH confounding or being misdiagnosed as psychotic symptoms needs to be borne in mind. PMID: 26816427 [PubMed - as supplied by publisher]
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
Last week, U.S. District Court Judge Thomas O’Neill of the Eastern District of Pennsylvania denied Cephalon’s motion to dismiss False Claims Act allegations brought by three former employees. Bruce Boise, Keith Dufour, and Andrew Augustine, joined by the United States, alleged that Cephalon promoted two drugs, Provigil and Nuvigil off-label (view the third amended complaint here). The complaint had additional weight due to the fact that Cephalon was under a Corporate Integrity Agreement during the alleged illegal conduct, which outlined “Stipulated Penalties for Failure to Comply” with a v...
Source: Policy and Medicine - Category: American Health Authors: Source Type: blogs
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