CUBN variants uncouple proteinuria from kidney function

Nature Reviews Nephrology, Published online: 13 December 2019; doi:10.1038/s41581-019-0242-4A new study links pathogenic cubilin gene (CUBN) variants to proteinuria without progressive renal impairment, providing reassurance for a subset of patients, calling into question the accepted pathogenesis of glomerulosclerosis and suggesting future therapeutic options.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research

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CONCLUSION: Urine dipstick proteinuria of 2+ or greater was significantly associated with the increased risk for incident gallstone. PMID: 31956168 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - Category: Epidemiology Tags: J Epidemiol Source Type: research
A 52-year-old farmer was admitted with recurrent fever for>1 year, hematuria, proteinuria, renal insufficiency, and anemia for 4 months. He lost 15 kg over 1 year. He was employed in the animal husbandry industry including breeding of cattle and sheep and slaughtering cattle. On admission, the patient was afebrile and his blood pressure was 110/70 mm  Hg. Physical examination revealed 3 enlarged lymph nodes bilaterally in the inguinal area and was otherwise normal.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Preeclampsia is a common obstetric syndrome affecting women in their first pregnancy and characterized by hypertension and proteinuria, which appears after 20  weeks of gestation. It is characterized by high bl...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
AbstractA 39 ‐years‐old woman, was diagnosed with limited pulmonary granulomatosis with polyangiitis (GPA) five years ago.She was treated with methotrexate 15mg/week subcutaneously, oral glucocorticoids (0.5mg/kg/day) and trimethoprim ‐sulfamethoxazole (160mg‐800mg/day) with good clinical response. Three years later, while still on therapy, re‐evaluation revealed mild anemia (Hb:11.4g/dL), increased C‐reactive‐protein (62mg/L, normal‐value
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: CLINICAL IMAGE Source Type: research
Authors: Liu Y, Shi C, Fan J, Wang B, Li G Abstract Introduction: Multiple studies have revealed a strong relationship between the development of nephropathy and hepatitis B virus (HBV) infection. The underlying pathogenesis of hepatitis B-related glomerulonephritis (HBV-GN) involves immune complexes, which can be isolated from kidney tissues. Clearance of HBV antigenemia improves renal impairment and proteinuria in HBV-GN patients.Areas covered: In this review, we present our current understanding of the epidemiology, pathogenesis, pathology, diagnosis, and treatment of HBV-GN. We discuss the advantages and disadv...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Publication date: Available online 16 January 2020Source: American Journal of Kidney DiseasesAuthor(s): Jelmer K. Humalda, Gerald Klaassen, Hanne de Vries, Yvette Meuleman, Lara C. Verschuur, Elisabeth J.M. Straathof, Gozewijn D. Laverman, Willem Jan W. Bos, Paul J.M. van der Boog, Karin M. Vermeulen, Olivier A. Blanson Henkemans, Wilma Otten, Martin H. de Borst, Sandra van Dijk, Gerjan J. Navis, P.J.M. van der Boog, S. van Dijk, G.J. Navis, J.K. Humalda (project coordination), G. KlaassenRationale &ObjectivePatients with chronic kidney disease (CKD) are particularly sensitive to dietary sodium. We evaluated a self-man...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Abstract BACKGROUND: Proteinuria is common in kidney transplant recipients and has been established as a risk factor for graft-loss and mortality. In the general population, proteinuria has also been tied to a higher risk of cardiovascular disease. There is limited data exploring the association between changes in proteinuria over time and cardiovascular disease in kidney transplant recipients. METHODS: In this retrospective cohort study we evaluated proteinuria as a time-varying covariate using urine dipstick protein values at 6 month intervals post-transplant. The primary outcome was the occurrence a m...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
AbstractIgA nephropathy (IgAN) is one the most common primary glomerulonephritis in children and adolescents worldwide, with 20% of children developing end-stage kidney disease (ESKD) within 20  years of diagnosis. There is a need for treatment guidelines, especially for steroids in children with primary IgAN, since the STOP-IgA trial casts doubts on the use of steroids in adults with intermediate risk. Pediatricians are prone to prescribe steroids in addition to renin–angiotensin syste m blockade (RASB) when proteinuria is>  0.5 g/l, eGFR deteriorates 
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study was designed to evaluate whether helminthic infections suppress the natural development of systemic lupus erythematosus (SLE) in NZBWF1 mice. Infection of NZBWF1 SLE-prone mice with two nematodes failed to establish long-lasting settlement. However, the Hymenolepis microstoma (Hm) rodent tapeworm successfully established long-term parasitization of NZBWF1 mice and was used to evaluate the suppressive effects of helminth infection. Ten-month-old NZBWF1 mice developed symptoms including autoantibody generation, proteinuria, glomerular histopathology, and splenomegaly, but mice infected with Hm at 2 months of age...
Source: Parasitology International - Category: Parasitology Source Type: research
CONCLUSIONS: In individuals with CKD, prediabetes was not associated with composite renal outcome, but was associated with an increased risk of proteinuria progression and adverse CV outcomes. PMID: 31943096 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
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