CUBN variants uncouple proteinuria from kidney function

Nature Reviews Nephrology, Published online: 13 December 2019; doi:10.1038/s41581-019-0242-4A new study links pathogenic cubilin gene (CUBN) variants to proteinuria without progressive renal impairment, providing reassurance for a subset of patients, calling into question the accepted pathogenesis of glomerulosclerosis and suggesting future therapeutic options.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research