Alteration of Extracellular Matrix Molecules and Perineuronal Nets in the Hippocampus of Pentylenetetrazol-Kindled Mice.

This study shows that possibility of changes in extracellular matrix molecules due to astrocyte activation is associated with epilepticus in PTZ-kindled mice. PMID: 31827499 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research

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ConclusionTo the best of our knowledge, this is the first review dedicated to the characteristics of paediatric patients with PRS and epilepsy. Seizures are usually focal, became refractory in 40%, and have a significant impact on the quality of life and neurodevelopment of patients.
Source: Seizure - Category: Neurology Source Type: research
The objective of this study was to assess factors associated with research participation among epilepsy clinic patients who screened positive for anxiety or depression. This was accomplished by characterizing clinical and psychiatric factors among patients seen in an epilepsy clinic and evaluating which factors were associated with consent for potential research participation, via a combined clinical and research screening model.MethodsIn a pragmatic trial of anxiety and depression treatment in epilepsy, individuals with a positive screen for anxiety and/or depression at a routine epilepsy clinic visit were invited to opt-...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
The objective of the study was to validate the parent-proxy reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) in a sample of young adults with a history of childhood-onset epilepsy, allowing for the utilization of a consistent informant (the parent) across the youths' stages of development. The 55-item (QOLCE-55) and 16-item versions (QOLCE-16) were evaluated.MethodsData came from 134 young adults (aged 18.0 to 28.5 years) with childhood-onset epilepsy, recruited through community and tertiary care centers across Canada. Confirmatory factor analysis (CFA) was used to assess the higher-order factor stru...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsThe impression of and beliefs about epilepsy among the general population as well as among PWE were the primary factors affecting stigma. Thus, there is a need for the provision of accurate information about epilepsy to both these groups. Additional studies on epilepsy-associated stigma employing various methodological approaches are required.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, the current study shed light on the potential neuroprotective role of metformin and trimetazidine in the amelioration of cognitive function via hindering inflammatory processes in diabetic epileptic rats.Graphical abstractDiagram illustrating alterations in the hippocampus induced in diabetic epileptic rats. DAP, death-associated protein; ATP/ADP, ratio of adenosine triphosphate and adenosine diphosphate; mTOR, mammalian target of rapamycin; Casp-3, caspase-3; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB, nuclear factor-κB; IGF-1, insulin growth factor 1.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Two lines on a home pregnancy test, a flickering heartbeat on ultrasound, and suddenly your world has changed: you’re pregnant! Regardless of where this new path takes you, you may start to examine your daily decisions in a new way as you discover an intense drive to protect the growing baby inside you. Even your exercise routines may come under scrutiny, particularly if late-night Googling has you second-guessing everything that you believed you knew. Just how safe is exercise during pregnancy? The short answer? Exercise during pregnancy is not only safe, it’s encouraged. An overriding principle for pregnancy ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
ConclusionsACT-709478 exhibits good tolerability up to 100  mg once daily using an up-titration regimen and pharmacokinetic properties that support further clinical investigations. A weak induction of gastrointestinal cytochrome P450 3A4 activity was observed, unlikely to be of clinical relevance.ClinicalTrials.gov IdentifierNCT03165097.
Source: CNS Drugs - Category: Neurology Source Type: research
Mitochondrial disorders result from mutations in mitochondrial DNA or nuclear genes regulating mitochondrial DNA (mtDNA) function and maintenance. Clinical syndromes may be multi-systemic or tissue-specific, and typically present in childhood or early adulthood. Neurological manifestations such as epilepsy are common, as neurons are particularly susceptible to mitochondrial dysfunction given their high metabolic demand [1]. However, case reports documenting the first presentation of a suspected mitochondrial disease above the age of 70 years are exceedingly rare.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Clinical letter Source Type: research
For the 20 –30 % of patients with temporal lobe epilepsy (TLE) refractory to medical therapy, resective brain surgery is an effective option that results in seizure freedom in approximately two-thirds of cases [1]. Surgical disconnection of the epileptogenic tissue is the goal of each type of epilepsy surger y, and in TLE this typically occurs with resection of the hippocampus, amygdala, and/or the anterior temporal lobe [2]. Development of technology that allows for more accurate and precise surgical target mapping or better identification of ideal surgical candidates may lead to a higher rate of seizu re-freedom in...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
This study is aimed at investigating optimum extraction of protein-rich extracts from BB (BBPs) using response surface methodology (RSM) and exploring the protective effects of BBPs against nerve growth factor (NGF)-induced PC12 cells injured by glutamate (Glu) and their underlying mechanisms. The results indicated optimum process of extraction was as follows: extraction time 1.00 h, ratio of liquid to the raw material 3.80 mL/g and ultrasonic power 230.0 W. The cell viability of PC12 cells stimulated by Glu was determined by CCK-8 assay. The levels of γ-aminobutyric (GABA), interleukin-1β (IL-1&beta...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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