Boys born small at heightened risk of infertility as adults

Mother ’s health and lifestyle during pregnancy may be important factors in restricting foetal growth and reproductive capacity, suggest researchers Related items fromOnMedica Inducing labour in late pregnancies is safer approach Monitor women better to cut stillbirth rates Doctors demand action on drinking in pregnancy Fetal exposure to nicotine linked to later obesity Exercise throughout pregnancy is safe and beneficial
Source: OnMedica Latest News - Category: UK Health Source Type: news

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The impact of female abnormalities of body mass index (BMI) and its association with subfertility and increased time to pregnancy (TTP) have been well-characterized (1). This may be due to the impact of BMI on ovulatory status in women, though TTP is increased even among women with a high BMI and reportedly regular cycles (2). Patients with higher BMIs, those in the overweight and obese categories, are at increased risk for gestational issues including gestational diabetes, hypertension, and difficulty with fetal monitoring.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study provides further evidence that maternal PCOS and/or anovulatory infertility, independently and jointly with maternal obesity, perinatal problems, gestational diabetes and cesarean delivery, implies a broad range of adverse effects on offspring neurodevelopment. These findings may potentially help in counseling and managing pregnancies.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by the joint research funding of Shandong University and Karolinska Institute (SDU-KI-2019-08 to X.C and C.L.), THL Finnish Institute for Health and Welfare: Drug and pregnancy project [M.G.], the Swedish Research Council ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: Pregnancy and fertility rates in very obese women with PCOS after bariatric surgery were high, with few maternal and neonatal complications. PMID: 32754732 [PubMed - in process]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Authors: Rehnitz J, Rösner S, Harsch J, Dietrich J, Bruckner T, Capp E, Strowitzki T, Germeyer A Abstract Introduction Azoospermia affects about 1% of men, of whom up to 15% inquire about infertility treatment. Information about predictive factors for these couples is very limited. Patients, Materials and Methods We performed a retrospective analysis of the clinical records of 118 cycles of intracytoplasmic sperm injection treatment after testicular sperm extraction for male azoospermia carried out between January 2008 and October 2015. Of those, 66 were first, 35 second, and 17 third cycles. Statistical signi...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
This study investigated the association between preconception body mass index (BMI) and time to pregnancy (TTP) in women planning to conceive from Shanghai, China. A total of 1,182 women aged 24-46 years were recruited from the Shanghai Birth Cohort between 2013 and 2015 and were followed up for 12 months. Preconception BMI was categorized as underweight, normal weight, and overweight/obesity according to the Chinese classification of BMI. Fecundability (FOR) and infertility (IOR) odds ratios were estimated using Cox (n = 1,092) and Logistic (n = 820) regression models, respectively. We found ...
Source: Women and Health - Category: Primary Care Authors: Tags: Women Health Source Type: research
Conclusions and Relevance A myriad of patient and environmental factors impact the potential success rates of IVF in treating infertility. Providers must be equipped to provide data-driven, patient-centered counseling before initiation of IVF. Target Audience Obstetricians and gynecologists, family physicians. Learning Objectives After completion of this CME article, readers should be better able to explain the importance of IVF in treating infertility for a variety of patient populations; describe current recommendations and best practices for preconception workup and counseling; identify important risk factors an...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
CONCLUSION: We observed some trends and slight difference between outcomes of women with low versus high BMI. There are only a few studies on infertile women with low BMI, and further investigation is warranted. PMID: 32370724 [PubMed - as supplied by publisher]
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
ConclusionBlastocyst formation did not differ based on race or BMI.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Publication date: Available online 10 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Michael Fenech, Nina Holland, Micheline Kirsch-Volders, Lisbeth E. Knudsen, Karl-Heinz Wagner, Helga Stopper, Siegfried Knasmueller, Claudia Bolognesi, Randa El-Zein, Stefano BonassiAbstractThe “Micronuclei and Disease” workshop was organized by the HUMN Project consortium and hosted by the European Environmental Mutagen and Genomics Society at their annual meeting in Rennes, France, on 23 May 2019. The program of the workshop focused on addressing the emerging evidence linking ...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
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