Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis

ConclusionsVitamin D insufficiency was prevalent in both newly diagnosed axSpA patients and healthy controls. There was no association between vitamin D and pain and disease activity in the newly diagnosed axSpA patients. Monitoring vitamin D levels is important and early intervention for vitamin D insufficiency is needed, especially in female patients.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research

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ConclusionsOur results revealed that the presence of NP component in patients with AS is associated with various disease ‐related variables, including pain, high disease activity, reduced mobility of the axial skeleton, depression and poor quality of life.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
HORSHAM, PA, September 30, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved SIMPONI ARIA® (golimumab) for patients 2 years of age and older for the treatment of active pJIA and has extended the PsA indication for this same patient population. “This latest FDA approval of SIMPONI ARIA for pediatric use in active pJIA and active PsA not only brings a new option to young patients living with these diseases but also adds to the growing body of evidence for this treatment,” said Mathai Mammen, M.D., Ph.D., Glob...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
In August, Abbvie submitted a new drug application for upadacitinib to treat ankylosing spondylitis. And in September, the FDA approved an oral solution of tramadol hydrochloride for pain.
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Drug Updates ankylosing spondyl­itis Ankylosing spondylitis (AS) FDA Pain Pain Management tramadol hydrochloride U.S. Food and Drug Administration (FDA) upadacitinib Source Type: research
ConclusionsOur study found that visits to the ED by patients with inflammatory rheumatic diseases were classified as urgent or less urgent. Patients with rheumatoid arthritis were the most numerous ED visitors. Vasculitis was the most common cause of hospitalization in the wards and scleroderma was the most common cause of hospitalization in the ICU and death. This suggests that ED physicians should be aware of these patients.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractFibromyalgia (FM) is known a common painful syndrome and its frequency is increased in inflammatory rheumatic diseases. We aimed to assess FM frequency in axial spondyloarthritis (AxSpA) patients and age- and sex-matched healthy controls with the 2011 ACR FM criteria. We evaluated the association between receiving biologic disease-modifying antirheumatoid drugs (bDMARD) and presence of FM. 127 patients with Ax-SpA and 73 age- and sex-matched controls were included. Individuals were assessed according to modified 2011 ACR diagnostic criteria for FM. The pain was evaluated by visual analog scale (VAS). Disease activi...
Source: Rheumatology International - Category: Rheumatology Source Type: research
This study aimed to evaluate fatigue and its relationship with disease parameters, functional disability, anxiety, depression, quality of life, and correlation with disease activity as determined by various scales. A total of 1028 patients (677 females, 351 males) with PsA who met the CASPAR criteria were included [Turkish League Against Rheumatism (TLAR) Network multicenter study]. The demographic features and clinical conditions of the patients were recorded. Correlations between fatigue score and clinical parameters were evaluated using the Disease Activity Score 28 (DAS28), Disease Activity in Psoriatic Arthritis (DAPS...
Source: Rheumatology International - Category: Rheumatology Source Type: research
ConclusionPsA-associated fatigue is prevalent in this Asian PsA cohort and is associated with disease activity, impact and chronicity.
Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
AbstractThe patient, a 26 ‐year old woman diagnosed with HLA‐B27‐associated ankylosing spondylitis (AS) currently not on therapy complained of new‐onset mid‐back pain. The pain was particularly noticeable during inspiration and yawning. Point tenderness at two costo‐vertebral joints (CVJ) on both sides of the spi ne was noted. Electrocardiogram and chest X‐ray were unremarkable. Laboratory studies showed elevated inflammatory markers. Magnetic Resonance Imaging (MRI) of the spine and sacroiliac joints (SIJ) revealed left‐sided sacroiliitis.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: CLINICAL IMAGE Source Type: research
Rationale: Ankylosing spondylitis (AS) and Kimura's disease (KD) which is quite rare are both chronic inflammatory diseases. Recently we encountered a patient who suffered from KD and AS, and some of his family members also suffer from AS. We, therefore, investigated this unique case and conducted the family-based whole exome sequencing to explore the possible genetic alterations. Patient concerns: Here, we reported a case of a 44-year-old Chinese man with multiple painless masses all over his body and a back pain for 32 years. His uncle and sister were diagnosed with AS. Diagnosis: The diagnosis of KD was based on...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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