A Research Nonprofit Shutters TB Vaccine Effort and Lays Off Scientists

A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Infectious Disease Research Institute Vaccination and Immunization Tuberculosis Philanthropy Nonprofit Organizations Drugs (Pharmaceuticals) Leprosy (Hansen ' s Disease) Leishmaniasis Layoffs and Job Reductions Seattle (Wash) your- Source Type: news

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Sattamma, a daily labourer in the Rangareddy district of southern India’s Telangana state, says that even though she no longer has Hansen’s Disease, she remains discriminated against because of it. Credit: Stella Paul/IPSBy Stella PaulHYDERABAD, India , Jan 23 2020 (IPS) Fifteen years ago, Sattamma – a daily labourer in the Rangareddy district of southern India’s Telangana state – was abandoned by her husband after she was diagnosed with Hansen’s Disease. Last October, while her neighbours were celebrating Diwali, Sattamma was homeless again as her landlord threw her out of the house aft...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Development & Aid Editors' Choice Featured Global Headlines Health Human Rights Latin America & the Caribbean Poverty & SDGs TerraViva United Nations Brazil Hansen's disease India Indonesia leprosy Source Type: news
This study examines Nigerian stakeholders’ insights to characterize the mechanisms, enabling structures and influences that lead programs to succeed or fail.Eight focus group discussions were held with Community Health Workers (CWs) from four models of community-based TB screening and referral. In-depth interviews were conducted with 2 State TB program managers, 8 Community based organizations (CBOs), and 6 state TB and Leprosy Local Government supervisors. Transcripts were coded using Framework Analysis to assess how divergent understandings of CWs’ roles, expectations, as well as design, political and structu...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Infectious Disease Research Institute Vaccination and Immunization Tuberculosis Nonprofit Organizations Drugs (Pharmaceuticals) Leprosy (Hansen ' s Disease) Leishmaniasis Layoffs and Job Reductions Seattle (Wash) your-feed-healthcare Source Type: news
By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
Abstract Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and sporadic cases of Parkinson's disease but are also found in immune-related disorders such as inflammatory bowel disease, tuberculosis and leprosy. LRRK2 is highly expressed in immune cells and has been functionally linked to pathways pertinent to immune cell function, such as cytokine release, autophagy and phagocytosis. Here, we examine the current understanding of the role of LRRK2 kinase activity in pathway regulation in immune cells, drawing upon data from multiple diseases associated with LRRK2 to highlight th...
Source: Biochemical Society Transactions - Category: Biochemistry Authors: Tags: Biochem Soc Trans Source Type: research
In this study, we investigated the synergistic effect of high-dose NO combined with amikacin and clofazimine against M. abscessus. We have used a NO Exposure Chamber to test the susceptibility of three M. abscessus clinical strains (MAB-062600, MAB-030804, and MAB-010708) and ATCC 19977 to NO and its combination with clofazimine and amikacin. Disc Diffusion or E-test methods was used to determine the minimum inhibitory concentrations (MICs) for each strain followed by Agar Dilution method to determine synergistic effects. Treatment with 250ppm NO alone for 10hr demonstrated a 5- to 6-log reductions in M. abscessus clinical...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Abstract A common technique used to differentiate bacterial species and to determine evolutionary relationships is sequencing their 16S ribosomal RNA genes. However, this method fails when organisms exhibit high similarity in these sequences. Two such strains that have identical 16S rRNA sequences are Mycobacterium indicus pranii (MIP) and Mycobacterium intracellulare. MIP is of significance as it is used as an adjuvant for protection against tuberculosis and leprosy; in addition, it shows potent anti-cancer activity. On the other hand, M. intracellulare is an opportunistic pathogen and causes severe respiratory i...
Source: Analytical and Bioanalytical Chemistry - Category: Chemistry Authors: Tags: Anal Bioanal Chem Source Type: research
Authors: Pradana KA, Widjaya MA, Wahjudi M Abstract In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Conditions:   Tuberculosis;   Adherence, Patient;   Adherence, Medication;   Drug-resistant Tuberculosis Interventions:   Behavioral: Keheala Mobile Health Platform and Behavioral Interventions;   Behavioral: Social and Behavior Change Communication (SBCC);   Behavioral: SMS Reminder;   Other: Standard of Care Sponsors:   Massachusetts Institute of Technology;   Keheala;   United States Agency for International Development (USAID);   Kenya National Tuberculosis, Leprosy and Lung Disease Program;   McGill&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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