Use of Molecular Biomarkers to Inform Adjuvant Therapy for Colon Cancer

In this review, we will discuss adjuvant chemotherapy in non-metastatic colon cancer, the existing prognostic and predictive molecular biomarkers in the field, and how to integrate these molecular biomarkers into the decision about whether to administer adjuvant therapy.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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ConclusionAlthough classically, majority of studies have shown oncogenic roles of nucleoporins as genetic fusion partners in several types of leukemia, emerging evidence suggests that nucleoporins also modulate many cellular signaling pathways that are associated with several major non-hematological malignancies, such as carcinomas of skin, breast, lung, prostate and colon. Hence, nucleoporins are emerging as novel therapeutic targets in human tumors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Surgical oncologists consider the patient's condition and postoperative course rather than high-risk factors to determine use of AC. Regardless of AC use, both the extent of surgery and the patient's subsequent status affected the survival rate in the high-risk group. None of the factors identified influenced survival rate in the low-risk group. PMID: 31726001 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
CONCLUSIONS: The Naples prognostic score may be a useful prognostic marker in patients with metastatic colorectal cancer receiving systemic chemotherapy. See Video Abstract at http://links.lww.com/DCR/B72. LA PUNTUACIÓN PRONÓSTICA DE NÁPOLES ES UN MARCADOR PRONÓSTICO ÚTIL EN PACIENTES CON CÁNCER COLORRECTAL METASTÁSICO ANTECEDENTES: La inflamación sistémica puede influir en la respuesta a la quimioterapia sistémica o el pronóstico en pacientes con varios tipos de cáncer. La puntuación pronóstica de Nápoles, basada...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Functional FoodsAuthor(s): Mónica Lara-Márquez, Marisol Báez-Magaña, Cristina Raymundo-Ramos, Paul A. Spagnuolo, Lourdes Macías-Rodríguez, Rafael Salgado-Garciglia, Alejandra Ochoa-Zarzosa, Joel E. López-MezaAbstractColorectal cancer (CRC) is the third most common type of cancer worldwide. Chemotherapy used in CRC patients has severe side effects. As an alternative, the search to identify natural compounds increases the opportunity to select therapeutics. In this work, the cytotoxic effect of a lipid extra...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Conditions:   Patient Empowerment;   Patient Activation;   Self Care;   Cancer of Colon;   Cancer of Rectum Intervention:   Behavioral: Educational nursing intervention on nutrition intake related chemotherapy induced side-effects' self-care among the patients with colorectal cancer Sponsors:   University of Turku;   Helsinki University Central Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsExpectedly, adjuvant radiation use was relatively low but was associated with improved OS in patients with both pT4 and positive margins.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Collectively, successful delivery of miR and chemotherapy by pH ‐responsive targeting nanoparticles modulates β‐catenin/multiple drug resistance/apoptosis/metastasis pathways and induces cancer cell death, mainly via apoptosis. These pH‐sensitive targeting nanoparticles carrying chemotherapy and gene therapeutics remarkably enhance anticancer efficacy in tumor‐bearing mice. Thus, these nanoparticles may provide a potential regimen for effective treatment of colorectal cancer. AbstractIrinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA ‐200 (miR‐200) has been reported...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
CONCLUSIONS: Future studies can consider sustained attention constructs when studying cognitive function in colon cancer patients. PMID: 31711102 [PubMed - as supplied by publisher]
Source: Archives of Clinical Neuropsychology - Category: Psychiatry & Psychology Authors: Tags: Arch Clin Neuropsychol Source Type: research
Collectively, successful delivery of miR and chemotherapy by pH ‐responsive targeting nanoparticles modulates β‐catenin/multiple drug resistance/apoptosis/metastasis pathways and induces cancer cell death, mainly via apoptosis. These pH‐sensitive targeting nanoparticles carrying chemotherapy and gene therapeutics remarkably enhance anticancer efficacy in tumor‐bearing mice. Thus, these nanoparticles may provide a potential regimen for effective treatment of colorectal cancer. AbstractIrinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA ‐200 (miR‐200) has been reported...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
ConclusionsLaparoscopic resection following stent insertion for obstructing colon cancer can be performed safely, with long-term oncologic outcomes comparable with those of open surgery.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
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