The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities

Nature Reviews Endocrinology, Published online: 13 December 2019; doi:10.1038/s41574-019-0286-3The dominant immune cell type causing pancreatic islet inflammation in individuals with obesity and/or type 2 diabetes mellitus is the macrophage. In this Review, we focus on the characteristics of inflammation in obese or type 2 diabetes mellitus islets and the consequences of this with respect to β-cell function.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research