Predictors of Left Ventricular Dysfunction after Surgery for Degenerative Mitral Regurgitation.

This study was performed to determine if strain can supplement the ability of left ventricular ejection fraction (LVEF) to predict post-op ventricular dysfunction in patients undergoing mitral valve (MV) surgery for degenerative mitral regurgitation (DMR). METHODS: From 2004 to 2017, 520 patients with an LVEF> 60% underwent MV surgery (98% repair) for DMR. All patients had preoperative (pre-op), pre-discharge (pre-dsg) and follow-up (F/U) (mean 5.0±3.6 years) echocardiograms. Speckle tracking was performed in 119/520 (22.9%) patients to determine LV strain, right ventricular (RV) free-wall strain, and left atrial longitudinal strain. Multivariate logistic and Cox regression models were used in this subgroup to evaluate associations with early postoperative LV dysfunction and medium-term overall survival, respectively. RESULTS: Median pre-op LVEF of the entire cohort was 65%. Based on pre-dsg echo, 449 patients (86.3%) maintained postoperative LVEF> 50%. 71 patients (13.7%) had a pre-dsg LVEF
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

Related Links:

In conclusion, we succeeded in generating an iPSC-based RAG2-SCID model, which enabled the identification of previously unrecognized disorder-related T cell developmental roadblocks.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
CONCLUSIONS Anterior cruciate ligament suture with the InternalBrace ligament augmentation judging from the results achieved by our group of patients brings very good clinical outcomes already at 6 months postoperatively. This method allows the athletes to return to full load soon. It maintains the kinematics and knee joint proprioception, and thus can potentially contribute to the prevention of post-traumatic arthritis. Strict application of indication criteria is a precondition to success. A longer follow up and evaluation of a larger number of patients will, however, be necessary to definitely confirm the success of thi...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
Primary and Stem Cell CultureThis just came across our radar." SUPPLEMENTARY MATERIAL An eye opener in stroke: Mitochondrial dysfunction and stem cell repair in MCAO induced retinal ischemia "We are always delighted when researchers supplement their cell culture media with ourFetal Bovine Serum (FBS).RPE Cells and MSC Culture Retinal pigmented epithelium (RPE, CRL-4000; ATCC) cells were cultured in Dulbecco ’s Modified Eagle Media/F-12 (DMEM/F-12, 11320033; Gibco) containing 10% fetal bovine serum (FBS; FBS001; Neuromics) and 0.01 mg/ml hygromycin B (10687010; Gibco) in incubator (37 °C humidified, with...
Source: Neuromics - Category: Neuroscience Tags: adult stem cells FBS Fetal Bovine Serum Human Mesenchymal Stem Cells MSCs Retinal Pigment Epithelial Cells RPES Source Type: news
Abstract PURPOSE: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. METHODS: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. RESULTS: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p
Source: Acta Cirurgica Brasileira - Category: Surgery Authors: Tags: Acta Cir Bras Source Type: research
Purpose of review Optic neuropathies refer to a collection of diseases in which retinal ganglion cells (RGCs), the specialized neuron of the retina whose axons make up the optic nerve, are selectively damaged. Blindness secondary to optic neuropathies is irreversible as RGCs do not have the capacity for self-renewal and have a limited capacity for self-repair. Numerous strategies are being developed to either prevent further RGC degeneration or replace the cells that have degenerated. In this review, we aim to discuss known limitations to regeneration in central nervous system (CNS), followed by a discussion of previous,...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Heather E. Moss Source Type: research
Publication date: Available online 15 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Harold G. Roberts, Lawrence M. Wei
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In this study, we identified microtubule-depolymerizing kinesin Kif2C as a protein associated with DSB-mimicking DNA templates and known DSB repair proteins inXenopus egg extracts and mammalian cells. The recruitment of Kif2C to DNA damage sites was dependent on both PARP and ATM activities. Kif2C knockdown or knockout led to accumulation of endogenous DNA damage, DNA damage hypersensitivity, and reduced DSB repair via both NHEJ and HR. Interestingly, Kif2C depletion, or inhibition of its microtubule depolymerase activity, reduced the mobility of DSBs, impaired the formation of DNA damage foci, and decreased the occurrence...
Source: eLife - Category: Biomedical Science Tags: Cell Biology Source Type: research
Higher rates of surgery for proximal humerus fracture among Medicare beneficiaries are associated with increased costs, adverse events, and mortality, according to new findings in JAMA Network Open.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Orthopaedics News Source Type: news
ConclusionWe believe that the best exposure for the correction of aberrant right subclavian artery is via a median sternotomy, especially in pediatric patients associated with other cardiac anomalies.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Genetic lineage tracing is widely used to study organ development and tissue regeneration. Multicolor reporters are a powerful platform for simultaneously tracking discrete cell populations. Here, combining Dre-rox and Cre-loxP systems, we generated a new dual-recombinase reporter system, called Rosa26 traffic light reporter (R26-TLR), to monitor red, green, and yellow fluorescence. Using this new reporter system with the three distinct fluorescent reporters combined on one allele, we found that the readouts of the two recombinases Cre and Dre simultaneously reflect Cre+Dre−, Cre−Dre+, and Cre+Dre+ cell lineage...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Developmental Biology Source Type: research
More News: Cardiovascular & Thoracic Surgery | Gastroschisis Repair | Study