Arrhythmias in Cardiac Amyloidosis: Challenges in Risk Stratification and Treatment

Publication date: Available online 12 December 2019Source: Canadian Journal of CardiologyAuthor(s): Christopher C. Cheung, Thomas M. Roston, Jason G. Andrade, Matthew T. Bennett, Margot K. DavisAbstractCardiac amyloidosis occurs secondary to the deposition of insoluble protein fibrils in cardiac tissue leading to progressive myocardial dysfunction, clinical heart failure, and arrhythmia. In recent years, increasing awareness and improved screening have resulted in an increased prevalence of cardiac amyloidosis, with contemporary estimates reporting a prevalence of 18 to 55 cases per 100,000 person-years, and accounting for more than 13% of heart failure hospitalizations. The arrhythmic manifestations of cardiac amyloidosis can range from conduction system disease and bradyarrhythmias to atrial fibrillation and sudden cardiac death. Bradyarrhythmias and conduction system disease may occur secondary to amyloid infiltration, but the timing of pacemaker implantation remains unclear. When available, biventricular pacing should be considered in symptomatic patients, particularly in those expected receive a high burden of ventricular pacing (>40%). The management of atrial fibrillation can be challenging, as contemporary agents for rate and rhythm control may be poorly tolerated in patients with cardiac amyloidosis. Patients with cardiac amyloidosis also have a high rate of intracardiac thrombus, and should be anticoagulated in the presence of atrial fibrillation (irrespective of...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

Related Links:

Jubilant Radiopharma has garnered Health Canada clearance for Drax Exametazime,...Read more on AuntMinnie.comRelated Reading: ITC upholds ruling in Jubilant-Bracco case Decision in Bracco-Jubilant case under review Jubilant forms new radiopharmaceutical company Jubilant DraxImage nets CE Mark for Rb-82 device Bracco hits Jubilant with patent complaint on rubidium PET
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
The objective of the study was to validate the parent-proxy reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) in a sample of young adults with a history of childhood-onset epilepsy, allowing for the utilization of a consistent informant (the parent) across the youths' stages of development. The 55-item (QOLCE-55) and 16-item versions (QOLCE-16) were evaluated.MethodsData came from 134 young adults (aged 18.0 to 28.5 years) with childhood-onset epilepsy, recruited through community and tertiary care centers across Canada. Confirmatory factor analysis (CFA) was used to assess the higher-order factor stru...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Canada confirmed its third case as the US Department of Health and Human Services and CDC says 20 airports across the country will screen for the deadly coronavirus that originated in China.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Eko, a maker of high-end digital stethoscopes, has just received the first FDA clearance for its devices to use AI algorithms to automatically detect atrial fibrillation (AFib) and heart murmurs. Using this capability, primary care physicians, who ar...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Pediatrics Source Type: blogs
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Muddassir Mehmood
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Chao Liu, Kunshen Liu
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Christopher M. O’Connor
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
ConclusionsIn this high-risk, low-income cohort, contributions of risk factors to HF varied, particularly by race. To reduce the population burden of HF, interventions tailored for specific race and sex groups may be warranted.Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Muddassir Mehmood
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: February 2020Source: JACC: Heart Failure, Volume 8, Issue 2Author(s): Jonathan N. Menachem, Kelly H. Schlendorf, Jeremy A. Mazurek, David P. Bichell, D. Marshall Brinkley, Benjamin P. Frischhertz, Bret A. Mettler, Ashish S. Shah, Sandip Zalawadiya, Wendy Book, JoAnn LindenfeldAbstractAs a result of improvements in care for patients with congenital heart disease (CHD),>90% of children born with CHD are expected to survive to adulthood. For those adults, heart failure (HF) is the leading cause of death. Advances in recognition of, and treatments for, these patients continue to improve. Specifically, adul...
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
More News: Amyloidosis | Arrhythmia | Atrial Fibrillation | Canada Health | Cardiology | Heart | Heart Failure | Thrombosis | Ventricular Arrhythmia