Urinary Prostaglandin E2 is a biomarker of early adaptive hyperfiltration in solitary functioning kidney

ConclusionIncreased urinary PGE2 from elevated SNGFR and consequently increased FFSS during early stage of CKD precedes overt microalbuminuria and is a biomarker for early hyperfiltration-induced injury in individuals with SFK.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research

Related Links:

Chronic kidney disease (CKD) is a public health threat with impact in cardiovascular risk. All forms of cardiovascular disease and mortality are more common in CKD. Treatment of cardiovascular risk factors, hypertension, dyslipidemia and diabetes is essential for cardiovascular and kidney protection. CKD is a marker of high or very high cardiovascular risk and its presence require early treatment and specific goals. Lifestyle is a pivotal factor, stopping smoking, reducing weight in the overweight or obese, starting regular physical exercise and healthy dietary pattern are recommended. Office BP should be lowered towards 1...
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
Objective: We studied clinical outcomes of COVID-19 infection in patients living with HIV (PLH) in comparison to non-HIV population. Design: Analysis of a multicentre research network TriNETX was performed including patients more than 10 years of age diagnosed with COVID-19. Methods: Outcomes in COVID-19 positive patients with concurrent HIV (PLH) were compared with a propensity-matched cohort of patients without HIV (non-PLH). Results: Fifty thousand one hundred and sixty-seven patients with COVID-19 were identified (49,763 non-PLH, 404 PLH). PLH were more likely to be men, African–American, obese and hav...
Source: AIDS - Category: Infectious Diseases Tags: FAST TRACK Source Type: research
Coronavirus disease 2019 (COVID-19) caused by SARS-COV-2 virus is a global pandemic impacting nearly 10 million people worldwide. Since the initial detection in December 2019, this novel coronavirus has posed major challenges to the human race. The disease has a varied spectrum of presentation with respiratory system being most commonly affected followed by the cardiovascular (CV) system in later stages of the disease.1 Multiple risk factors accounting for an adverse outcome include older age, male sex and presence of comorbidities such as diabetes, hypertension, chronic kidney disease and obesity.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
Abstract More frequent and intense periods of extreme heat (heatwaves) represent the most direct challenge to human health posed by climate change. Older adults are particularly vulnerable, especially those with common age-associated chronic health conditions (e.g., cardiovascular disease, hypertension, obesity, type 2 diabetes, chronic kidney disease). In parallel, the global population is aging and age-associated disease rates are on the rise. Impairments in the physiological responses tasked with maintaining homeostasis during heat exposure have long been thought to contribute to increased risk of health disord...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
We present the recommendations of the Brazilian Society of Nephrology regarding the treatment of pediatric patients with kidney diseases during the COVID-19 pandemic. METHODS: Articles and documents from medical societies and government agencies on specific recommendations for children on RRT in relation to COVID-19 as well as those focused on epidemiological aspects of this condition in Brazil Were evaluated and analyzed. RESULTS: We present recommendations on outpatient care, transportation to dialysis centers, peritoneal dialysis, hemodialysis, and kidney transplantation in children and adolescents during the CO...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
CONCLUSION: BP played a major role in renal progression in the general population with NRF. Strict BP control may help prevent CKD in the general population. PMID: 32864910 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Diet and nutrition can help improve overall and kidney health, but they can also cause kidney disease.1 Evidence suggests that high intake of dietary protein especially from animal sources may increase the risk of chronic kidney disease (CKD)2 in a similar way that high energy intake and presence of obesity often cause diabetes mellitus and cardiovascular disease. Once CKD is present, certain types of foods and other nutritional interventions such as a plant-dominant, low-protein diet or weight and body fat control can help slow the rate of CKD progression.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Editorial Source Type: research
AbstractThe COronaVirus DISease 19 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Older age and presence of comorbidities, including diabetes, were shown to be associated with a more severe course and a higher fatality rate. Studies from the most affected countries, including China, United States and Italy, seem to indicate that prevalence of diabetes among patients affected by COVID-19 is not higher than that observed in the general population, thus suggesting that diabetes is not a risk factor for SARS-CoV-2 infection. However, a l...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
SummaryObesity is a treatable risk factor for chronic kidney disease progression. We audited the reporting of body ‐mass index in nephrology outpatient clinics to establish the characteristics of individuals with obesity in nephrology practice. Body‐mass index, clinical information and biochemical measures were recorded for patients attending clinics between 3rd August, 2018 and 18th January, 2019. Inferential statistics and Pearson correlations were used to investigate relationships between body ‐mass index, type 2 diabetes, hypertension and proteinuria. Mean ± SD BMI was 28.6 ±&th...
Source: Clinical Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Original Research Article Source Type: research
lia González-Martínez Eduardo Campos-Góngora Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
More News: Children | Chronic Kidney Disease | Diabetes | Eating Disorders & Weight Management | Endocrinology | Ginger | Lipidology | Obesity | Urology & Nephrology