Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma.

Mesangiogenic progenitor cells are forced toward the angiogenic fate, in multiple myeloma. Oncotarget. 2019 Nov 26;10(63):6781-6790 Authors: Pacini S, Montali M, Mazziotta F, Schifone CP, Macchia L, Carnicelli V, Panvini FM, Barachini S, Notarfranchi L, Previti GB, Buda G, Petrini M Abstract Multiple myeloma (MM) progresses mainly in the bone marrow where the involvement of a specific microenvironment plays a critical role in maintaining plasma cell growth, spread, and survival. In active disease, the switch from a pre-vascular/non-active phase to a vascular phase is coupled with the impairment of bone turnover. Previously, we have isolated Mesangiogenic Progenitor Cells (MPCs), a bone marrow population that showed mesengenic and angiogenic potential, both in vitro and in vivo. MPC differentiation into musculoskeletal tissue and their ability of sprouting angiogenesis are mutually exclusive, suggesting a role in the imbalancing of the microenvironment in multiple myeloma. MPCs from 32 bone marrow samples of multiple myeloma and 23 non-hematological patients were compared in terms of frequency, phenotype, mesengenic/angiogenic potential, and gene expression profile. Defective osteogenesis was recorded for MM-derived MPCs that showed longer angiogenic sprouting distances respect to non-hematological MPCs, retaining this capability after mesengenic induction. This altered MPCs differentiation potential was not detected in asymptomatic m...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research