TGF β-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer.

We describe TGFβ signaling is involved in stimulating both glycolysis and mitochondrial respiration. Interestingly, the subsequent metabolic consequences for the redox state and lipid metabolism in cancer cells are found to be in favor of EMT as well. Combined we illustrate that a better understanding of the mechanistic links between TGFβ signaling, cancer metabolism and EMT holds promising strategies for cancer therapy, some of which are already actively being explored in the clinic.
PMID: 31822964 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - December 9, 2019 Category: Cytology Authors: Hua W, Ten Dijke P, Kostidis S, Giera M, Hornsveld M Tags: Cell Mol Life Sci Source Type: research